Pilot Study -- Galanin Neurons and Alzheimer's Disease Neuropathology

Gabriel, Steven M.

Abstract

The degeneration of basal forebrain cholinergic neurons is one of the hallmarks of Alzheimer's Disease. The recently isolated neuropeptide, galanin, has been found to be associated with magnocellular cholinergic perikarya in the nucleus basalis, suggesting its importance in the cholinergic deficits associated with this disease. This 29 amino acid, amidated peptide may represent a new peptide family and may function as an inhibitory neuromodulator throughout the body. This pilot project proposes to study the participation of galanin in the neuropathology associated with Alzheimer's Disease using reagents directed against human galanin, mRNA levels in normal and Alzheimer's Disease brain will be evaluated using northern blot techniques. In parallel to these studies, the distribution of human galanin peptide in normal and Alzheimer's Disease brain will be evaluated using a radioimmunoassay specific to human galanin. The data derived from these studies will provide important information concerning the role of galanin in the neuropathology and the symptoms associated with this Alzheimer's Disease.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Specialized Center (P50)
• Project #: 5P50AG005138-07
• Application #: 3809203
• Support Year: 7
• Fiscal Year: 1990

Institution

• Name: Mount Sinai School of Medicine
• City: New York
• State: NY
• Country: United States
• Zip Code: 10029

Publications

Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826

Girdhar, Kiran; Hoffman, Gabriel E; Jiang, Yan et al. (2018) Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome. Nat Neurosci 21:1126-1136

Huang, Qian; Voloudakis, Georgios; Ren, Yimin et al. (2018) Presenilin1/?-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. FASEB J 32:243-253

Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161

Giambartolomei, Claudia; Zhenli Liu, Jimmy; Zhang, Wen et al. (2018) A Bayesian framework for multiple trait colocalization from summary association statistics. Bioinformatics 34:2538-2545

Hauberg, Mads E; Fullard, John F; Zhu, Lingxue et al. (2018) Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls. Mol Psychiatry :

Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124

Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487

Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71

Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302