There is an existing need for talented veterinary scientists trained in basic and translational research who apply the principles of """"""""One Health"""""""" to discover the next generation of advances in medicine for the improvement of health in humans. This application for a new institutional T32 grant seeks funds to create an outstanding program for veterinarians to acquire the knowledge and skills in basic science, comparative medicine and translational research in order to develop and apply models of human disease for the purpose of improving human health. The specific goal of our Training Program is to nurture the development of DVM investigators in the broad field of biomedical research with the expectation that these individuals will go on to become independent investigators at academic institutions or industry. This will be achieved by pursing the following Specific Aims:
Aim 1) identify a diverse and well-qualified pool of applicants from across the country;
Aim 2) provide an inspiring didactic program that is tailored to each applicants learning agenda;
Aim 3) acquaint trainees with the ongoing approaches for basic and translational research related to human disease;
Aim 4) mentor the trainees in the design, execution, evaluation and presentation of experiments leading to original research and giving the trainees the skills required for independent careers in academics. Through this program, trainees will gain knowledge and technical skills to fully understand and evaluate the pathogenesis of disease in humans as well as animal models of human disease through both didactic coursework and applied training in microbiology, immunology and comparative medicine. Trainees will be able to find mentorship from a successful group of scientists who are dedicated to research training. The mentors/thesis advisors are comprised mostly of experienced preceptors from basic and translational research programs in microbiology, immunology and comparative medicine that include a cadre of veterinarians with an established record in post- graduate training and mentorship of DVM graduates. Their research programs utilize collaborative and multi- disciplinary approaches employing state-of-the-art techniques in cell biology, microbiology, molecular biology and comparative pathology. By observing strong, interactive programs in multiple departments at UCSD and throughout the research community in San Diego, the trainees will have an outstanding opportunity to pursue an agenda for successful professional development. This training program will be administered by faculty associated with the UCSD Center for Veterinary Sciences and Comparative Medicine. As a result of this training program, trainees will gain a comprehensive understanding of hypothesis-based research and gain knowledge and skills required for productive careers in academics that will address the national needs for the development of skilled scientists in mouse pathobiology and comparative medicine relevant to human health.

Public Health Relevance

There is an existing need for skilled scientists trained in basic and translational research to lead the next generation of advances in medicine that will improve human health. This application for an institutional T32 grant seeks funds to create an outstanding program for veterinarians to acquire the knowledge and skills in basic science and comparative medicine in order to develop and apply models of human disease for the purpose of improving human health.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Institutional National Research Service Award (T32)
Project #
1T32OD017863-01
Application #
8608344
Study Section
Special Emphasis Panel (ZOD1-CM-6 (02))
Program Officer
Moro, Manuel H
Project Start
2014-05-02
Project End
2019-04-30
Budget Start
2014-05-02
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$211,946
Indirect Cost
$13,486
Name
University of California San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Komori, H Kiyomi; LaMere, Sarah A; Hart, Traver et al. (2018) Microdroplet PCR for Highly Multiplexed Targeted Bisulfite Sequencing. Methods Mol Biol 1708:333-348
Sun, Qi; Lesperance, Jacqueline; Wettersten, Hiromi et al. (2018) Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest 128:531-544
Kurt, Timothy D; Aguilar-Calvo, Patricia; Jiang, Lin et al. (2017) Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem 292:19076-19086
Munguia, Jason; LaRock, Doris L; Tsunemoto, Hannah et al. (2017) The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance. J Mol Med (Berl) 95:1127-1136
LaMere, Sarah A; Thompson, Ryan C; Meng, Xiangzhi et al. (2017) H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol 199:3158-3175
Bett, Cyrus; Lawrence, Jessica; Kurt, Timothy D et al. (2017) Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun 5:32
Seguin, Laetitia; Camargo, Maria F; Wettersten, Hiromi I et al. (2017) Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov 7:1464-1479
Wettersten, Hiromi I; Aboud, Omran Abu; Lara Jr, Primo N et al. (2017) Metabolic reprogramming in clear cell renal cell carcinoma. Nat Rev Nephrol 13:410-419
Kurt, Timothy D; Sigurdson, Christina J (2016) Cross-species transmission of CWD prions. Prion 10:83-91
Trott, Josephine F; Kim, Jeffrey; Abu Aboud, Omran et al. (2016) Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget 7:66540-66557

Showing the most recent 10 out of 22 publications