Abstract

The Clinical Core is a critical component of the ADRC.
The Specific Aims of this Core are: 1) To follow annually, in person, a subset of previously recruited subjects (normal older adults, mild AD and Mild Cognitive Impairment (MCI) patients). Those patients who have transitioned to moderate/severe AD will be followed by telephone interviews. 2) To annually follow and recruit and 30 normal older adults, 30 MCI, 30 mild AD and 30 Parkinson's disease with dementia patients yearly with approximately 20-25% being African American. 3) To perform baseline and annual neuropsychological assessments on all recruited subjects. 4) To make available patients, caregivers, neuropsychological and clinical data to the leaders of the three ADRC Projects and to other investigators needing this information or subjects. 5) To continue to solicit and arrange autopsies on all subjects. 6) To work closely with the Data Management and Biostatistics Core to ensure that our data is of the highest quality and to ensure that it is transmitted to NACC in a timely fashion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016582-09
Application #
7404592
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
9
Fiscal Year
2007
Total Cost
$624,771
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Lassen-Greene, Caroline L; Steward, Kayla; Okonkwo, Ozioma et al. (2017) Mild Cognitive Impairment and Changes in Everyday Function Over Time: The Importance of Evaluating Both Speed and Accuracy. J Geriatr Psychiatry Neurol 30:220-227
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Niccolai, Lindsay M; Triebel, Kristen L; Gerstenecker, Adam et al. (2017) Neurocognitive Predictors of Declining Financial Capacity in Persons with Mild Cognitive Impairment. Clin Gerontol 40:14-23
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43

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