The USC Norris Comprehensive Cancer Center first participated in the research activities of SWOG in 1987 and was initially funded in 1992. This five-year grant cycle has had increased administrative and academic participation, with maintenance of high clinical and correlative trial entry, commensurate with available SWOG funding and added resources from USC. The major emphases of the USC team are (a) to provide leadership across the NTCN to design and efficiently perform clinical trials evaluating the safety and efficacy of novel regimens or modifications of existing regimens; (b) to provide leadership in biomarker development and in integration of new technologies into NCTN trials, taking advantage of a systematic approach to collection, processing, and storage of blood, normal tissue, fresh or frozen tumor tissue, and other relevant biologic samples for molecular and pharmacologic studies; and (c) to evaluate cancer treatment regimens in special patient populations, such as rare cancers, the elderly and ethnic minorities. USC investigators have not only contributed extensively to SWOG trials but have demonstrated administrative/academic leadership, facilitating the translation of specific themes of investigation to SWOG. Recent NCTN trials such as SWOG/ALLIANCE 80405 and S1401 characterizing metastatic colorectal and prostate cancer has significant increased the understanding of molecular subtyping and characterization of both cancers integrating cutting edge technologies including NGS testing and single cell molecular classification. USC UG1 members are playing an active role in NCI task forces and steering committees. As part of its dedication to cancer clinical research, USC has been successful in mentoring young investigators through the UM1 Career Development Awards, Project Team Memberships and SWOG Young Investigator Awards. USC has expanded its institutional training and mentoring capabilities. Lastly, as a Network Lead Academic Participating Site, USC will continue to bring unique strengths to the NCI National Clinical Trials Network thanks to its strength in recruitment of minorities to clinical trials, accrual to rare cancers such as biliary and bladder cancers, and a well- developed clinical research infrastructure.

Public Health Relevance

The overall objective of the USC UG1 Center is to provide the appropriate local infrastructure, governance, and support for the design, development, and conduct of innovative NCI-sponsored clinical trials within the NCTN. USC is uniquely positioned to play a leadership role because of its large and diverse patient population, its long history of active participation and scientific leadership in the national cooperative groups, especially SWOG, its scientific base and strengths in biomarker development, drug development, and identification of novel drugs targets and novel technologies essential for successful molecular diagnostics and monitoring.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1CA180830-08
Application #
10102208
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mooney, Margaret M
Project Start
2014-04-17
Project End
2025-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
8
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089