Abstract

CORE F - ABSTRACT This is a proposal to renew the Imaging Core for the UCSF Alzheimer's Disease Research Center (ADRC). The Imaging Core has supported the UCSF ADRC for nearly 10 years by managing acquisition, archiving and processing of high quality structural and functional MRI and PET datasets, and providing these data to ADRC and other investigators. In the coming cycle the Core will pursue the following aims: 1. Collection and archiving of MP-RAGE, FLAIR, T2-weighted, DTI, ASL perfusion, ICN-fMRI, and [18F]Florbetapir PET images, and maintenance of an image database. 2. Preprocessing of MP-RAGE images to correct for scanner-related artifacts and performing integrated image pre-processing for DW-MRI, ASL-MRI, ICN-fMRI, and PET images. 3. Extraction and uploading of data to common database, including processing and editing of T1-weighted images with FreeSurfer (FS) and production of cortical thickness measures and gray and white matter volumes for standard cortical and subcortical regions, and regional perfusion, and normalized amyloid tracer binding values for standard ROIs in FS space. 4. Enhancement of FS-based image processing by creation of disease-specific templates to serve as targets in FS for morphing new research images into standardized space and identifying gray and white matter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG023501-15
Application #
9472245
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
15
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Mok, Sue-Ann; Condello, Carlo; Freilich, Rebecca et al. (2018) Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol 25:384-393
Tan, Chin Hong; Fan, Chun Chieh; Mormino, Elizabeth C et al. (2018) Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol 135:85-93
Erkkinen, Michael G; Zúñiga, Raquel Gutiérrez; Pardo, Cristóbal Carnero et al. (2018) Artistic Renaissance in Frontotemporal Dementia. JAMA 319:1304-1306
Sturm, Virginia E; Brown, Jesse A; Hua, Alice Y et al. (2018) Network Architecture Underlying Basal Autonomic Outflow: Evidence from Frontotemporal Dementia. J Neurosci 38:8943-8955
Schneider, Raphael; McKeever, Paul; Kim, TaeHyung et al. (2018) Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. J Neurol Neurosurg Psychiatry 89:851-858
Bonham, Luke W; Geier, Ethan G; Steele, Natasha Z R et al. (2018) Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice. Front Neurosci 12:476
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Scheltens, Nienke M E; Tijms, Betty M; Heymans, Martijn W et al. (2018) Prominent Non-Memory Deficits in Alzheimer's Disease Are Associated with Faster Disease Progression. J Alzheimers Dis 65:1029-1039
Karch, Celeste M; Wen, Natalie; Fan, Chun C et al. (2018) Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA Neurol 75:860-875

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