The Cell and Tissue Core (CTC) will provide technical and personal support to facilitate, standardize and implement the collection, management and analysis of tissue samples. The CTC will support investigators by providing isolated chondrocytes or tissue for individual experiments. Anatomic evaluation of tissue also will be standardized within this Core. This Core Facility will serve all investigators who will be needing assistance with (1) collection of tissue and/or body fluid, (2) assistance with cell and tissue culture methods, and (3) anatomic evaluation of cells and/or tissue. The CTC intends to aid each SCOR project by providing technical, instrumental and personal support (i) which are commonly used by several projects or (ii) occasionally used by investigators but require special technical or safety regulations or (iii) require special equipment or technical expertise. The Cell and Tissue Culture Subunit of the CTC Core will facilitate the standardization of culture conditions, isolation of human and bovine chondrocytes, establishment of cell lines and organ cultures for SCOR Projects. The Human Tissue Appropriation Subunit of the CTC Core will provide the appropriate harvesting, storage and handling of tissues, cells and body fluids and generate and maintain a computer data base cataloging all tissues, with an appropriate grading scale. The Anatomic Evaluation of Tissue Subunit will coordinate the grading scale for human cartilage, and provide support for histological processing of tissue immunocytochemistry and flow cytometry, electron and confocal microscopy and other imaging techniques.
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| Tezcan, Mehmet E; Goker, Berna; Lidtke, Roy et al. (2017) Long-term effects of lateral wedge orthotics on hip and ankle joint space widths. Gait Posture 51:36-40 |
| Patchigolla, R Krishna R; Knudson, Warren; Schmid, Thomas M (2012) Matrix metalloproteinase-9 in a unique proteoglycan form in avian embryonic growth plate cartilage. Arch Biochem Biophys 520:42-50 |
| Anderson, Donald D; Chubinskaya, Susan; Guilak, Farshid et al. (2011) Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res 29:802-9 |
| Morris, Kirsten J; Cs-Szabo, Gabriella; Cole, Ada A (2010) Characterization of TIMP-3 in human articular talar cartilage. Connect Tissue Res 51:478-90 |
| Rolauffs, Bernd; Muehleman, Carol; Li, Jun et al. (2010) Vulnerability of the superficial zone of immature articular cartilage to compressive injury. Arthritis Rheum 62:3016-27 |
| Farlow, E C; Vercillo, M S; Coon, J S et al. (2010) A multi-analyte serum test for the detection of non-small cell lung cancer. Br J Cancer 103:1221-8 |
| Shakoor, Najia; Sengupta, Mondira; Foucher, Kharma C et al. (2010) Effects of common footwear on joint loading in osteoarthritis of the knee. Arthritis Care Res (Hoboken) 62:917-23 |
| Iacob, Stanca; Cs-Szabo, Gabriella (2010) Biglycan regulates the expression of EGF receptors through EGF signaling pathways in human articular chondrocytes. Connect Tissue Res 51:347-58 |
| Rolauffs, Bernd; Williams, James M; Aurich, Matthias et al. (2010) Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis. Arthritis Rheum 62:489-98 |
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