The vast majority of clinically evident osteoarthritis remains either idiopathic or related to some mechanical aberration in the joint stability or alignment. We propose that the osteoarthritic process is characterized by disturbance in the equilibrium between mechanical demands on the joint and the ability of joint tissues to support or adapt to those demands. Four individual projects are proposed to test this hypothesis. Project One further extends observations on the blunt impact animal model where the patellofemoral joint is loaded noninvasively by an externally applied force. This project will be utilized to study the cartilage damage and repair, the biology of the zone of calcified cartilage, and the response of subchondral bone. Project Two will study the canine spinal facet joints as an osteoarthritic model using dissolution of the intervertebral disc as an initiating agent to produce changes in the facet joints leading to degenerative arthritis. Biomechanical evaluation of forces and motions in the facet joints will be performed in vivo. Project Three will extend the study of excessive joint motion to humans, evaluating patients with anterior cruciate ligament deficient knees and normal subjects using a six-degree-of- freedom electrogoniometer during functional tasks. The possibility that neuromuscular control of the joint may influence the stability of the knee will be extended from Project Three to Project Four where the role of ligament and capsular innervation as an influencing element in joint stability and function will be studied in dogs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR039255-05
Application #
3105220
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1987-09-30
Project End
1993-05-31
Budget Start
1991-09-01
Budget End
1993-05-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Oegema Jr, T R; Carpenter, R J; Hofmeister, F et al. (1997) The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis. Microsc Res Tech 37:324-32
Lundberg, W R; Lewis, J L; Smith, J J et al. (1997) In vivo forces during remodeling of a two-segment anterior cruciate ligament graft in a goat model. J Orthop Res 15:645-51
Smith, J J; Lewis, J L; Mente, P L et al. (1996) Intraoperative force-setting did not improve the mechanical properties of an augmented bone-tendon-bone anterior cruciate ligament graft in a goat model. J Orthop Res 14:209-15
Chin-Purcell, M V; Lewis, J L (1996) Fracture of articular cartilage. J Biomech Eng 118:545-56
Schendel, M J; Dekutoski, M B; Ogilvie, J W et al. (1995) Kinematics of the canine lumbar intervertebral joint. An in vivo study before and after adjacent instrumentation. Spine (Phila Pa 1976) 20:2555-64
Chelberg, M K; Banks, G M; Geiger, D F et al. (1995) Identification of heterogeneous cell populations in normal human intervertebral disc. J Anat 186 ( Pt 1):43-53
Lewis, J L; Poff, B C; Smith, J J et al. (1994) Method for establishing and measuring in vivo forces in an anterior cruciate ligament composite graft: response to differing levels of load sharing in a goat model. J Orthop Res 12:780-8
Schwartz, M H; Leo, P H; Lewis, J L (1994) A microstructural model for the elastic response of articular cartilage. J Biomech 27:865-73
Mente, P L; Lewis, J L (1994) Elastic modulus of calcified cartilage is an order of magnitude less than that of subchondral bone. J Orthop Res 12:637-47
Dekutoski, M B; Schendel, M J; Ogilvie, J W et al. (1994) Comparison of in vivo and in vitro adjacent segment motion after lumbar fusion. Spine (Phila Pa 1976) 19:1745-51

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