This investigation will determine if the long term (8 weeks) administration of Hypericum perforatum to rats regulates ARTs similarly to, or differently from, long-term administration of prototypic antidepressant drugs. Additional data to be gained include the nature of any changes in ARTs during the course of Hypericum perforatum and whether this long-term administration regulates expression of genes thought to be activated during major depressive disorder (MDD). This study will offer information to be utilized to provide guidance in terms of dose and mechanism of action for subsequent phase I/II studies.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
3P50AT000151-04S1
Application #
6668215
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$159,181
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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