Prostate cancer has become one of the most frequently diagnosed cancers in men in the United States and a major cause of cancer morbidity and mortality. The transcendent objective of the Johns Hopkins Prostate Cancer SPORE is to reduce prostate cancer incidence and mortality via the focused pursuit of translational research in prostate cancer. This competitive renewal proposal, which has been revised in response to reviewer critiques, contains five Translational Research Projects, four Core Resources, two Career Development Projects, and two Developmental Research Projects: Dr. John Isaacs' Research Project exploits the enzyme activities of prostate-specific antigen (PSA) and human glandular kallikrein-2 (hGK2) for the selective activation of prostate-specific pro-drugs, Dr. Carducci's Research Project targets the use of inhibitors of DNA methylation along with inhibitors of histone deacetylation to restore """"""""silenced"""""""" gene expression in prostate cancer cells, Dr. Rodriguez's Research Project builds on an already successful translational research program, the development of cytolytic adenoviruses as prostate cancer gene therapy, by attempting to improve both the selectivity and lethality of replication-restricted cytolytic adenoviruses for prostate cancer cells in such a way as to increase prostate cancer treatment efficacy, Dr. Nelson's Research Project pursues the development of sulforaphane as a prostate cancer prevention agent, and Dr. William Isaacs' Research Project explores the contribution of genetic determinants of oxidative cell and genome damage and repair to prostate cancer risk in population studies. Each of the Research Projects features translation of innovative scientific concepts to human clinical trials or to population studies. The Research Projects are supported by Core Resources for Administration, for a Tissue Archive, for Biomarker Development, and for Biostatistics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA058236-13
Application #
7231470
Study Section
Special Emphasis Panel (ZCA1-GRB-G (M1))
Program Officer
Hruszkewycz, Andrew M
Project Start
1992-09-30
Project End
2008-08-31
Budget Start
2007-04-01
Budget End
2008-08-31
Support Year
13
Fiscal Year
2007
Total Cost
$2,532,522
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Bhanvadia, Raj R; VanOpstall, Calvin; Brechka, Hannah et al. (2018) MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clin Cancer Res 24:3668-3680
Antonarakis, Emmanuel S; Lu, Changxue; Luber, Brandon et al. (2018) Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide. Eur Urol 74:218-225
Joshu, Corinne E; Peskoe, Sarah B; Heaphy, Christopher M et al. (2018) Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells. Prostate 78:233-238
Krueger, Timothy E G; Thorek, Daniel L J; Denmeade, Samuel R et al. (2018) Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise. Stem Cells Transl Med 7:651-663
Shrestha, Eva; White, James R; Yu, Shu-Han et al. (2018) Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer. J Urol 199:161-171
Lu, Yunqi; Hu, Zhongyi; Mangala, Lingegowda S et al. (2018) MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels. Cancer Res 78:64-74
Das, Swadesh K; Pradhan, Anjan K; Bhoopathi, Praveen et al. (2018) The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion. Cancer Res 78:2852-2863
Karnes, R Jeffrey; Choeurng, Voleak; Ross, Ashley E et al. (2018) Validation of a Genomic Risk Classifier to Predict Prostate Cancer-specific Mortality in Men with Adverse Pathologic Features. Eur Urol 73:168-175
Menezes, Mitchell E; Bhoopathi, Praveen; Pradhan, Anjan K et al. (2018) Role of MDA-7/IL-24 a Multifunction Protein in Human Diseases. Adv Cancer Res 138:143-182
Jiang, Wen; Ulmert, David; Simons, Brian W et al. (2018) The impact of age on radium-223 distribution and an evaluation of molecular imaging surrogates. Nucl Med Biol 62-63:1-8

Showing the most recent 10 out of 750 publications