The continued hypothesis of this application is that a Specialized Program of Research Excellence (SPORE) in Prostate Cancer at the University of Michigan Comprehensive Cancer Center will reduce the morbidity and translational research program directed at understanding the biology of prostate cancer as well as developing new tools for the diagnosis, prevention, and treatment of prostate cancer. Specifically, this SPORE consists of nine multidisciplinary research projects that place special emphasis on (A) Molecular and Clinical Epidemiology: Implications for diagnosis, prognosis and screening with projects that include: Project 1. """"""""Gain of 8q as a Prostate Cancer in African Americans"""""""" (J. Macoska, T. Glover, J. Montie). Project 2. """"""""Epidemiology of Prostate Cancer in African Americans"""""""" (J. Montie, D. Schottenfeld, K. Cooney, K. Alcser). Project 3. """"""""Hereditary Prostate Cancer in African American Families (K. Cooney, J. Montie, D. Schottenfeld). Career Development Project 1. """"""""Cloning and Characterization of a Gene Associated with Metastatic Prostate Cancer"""""""" (E. Schwab, Career Development). (B) Novel Therapeutics: Implications for Prevention and Treatment with projects that include: Project 4. """"""""Rb as a Regulator of Prostate Tumorigenesis"""""""" (M. Day, B. Redman). Project PSA for Androgen-Modulated, Post-Surgical Recurrence for Prostate Cancer"""""""" (M. Sanda, D. Smith). Career Development Project 2. """"""""PHSCN and Related Peptides: Novel Anti-Invasive and Anti-Metastatic Therapeutic Radiation, Hormone Withdrawal, and Chemotherapy in Human Prostate Cancer Cells"""""""" (M. Ljungman). In American men (Projects 2 and 3) and Prostate cancer metastasis (Projects 5, CD 1, CD 2). The research projects are supported by three cores: Core 1. Administration (K. Pienta). Core 2. Tissue and Animal Models (K. Wojno, M. Sanda, K. Pienta). Core 3 Biostatistics (D. Normolle). This SPORE application continues to place emphasis on developmental and pilot projects as well as career development. The development program includes a rigorous scientific review process and the pairing of scientists in developmental proposals with basic science and clinical resource mentors. This SPORE infrastructure has been fully integrated into the Cancer Center and a strong institutional commitment remains in place.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1 (M1))
Program Officer
Hruszkewycz, Andrew M
Project Start
Project End
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Budget End
Support Year
Fiscal Year
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
Zip Code
Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria K et al. (2018) Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized. BMC Cancer 18:478
Xie, Yuanyuan; Cao, Zhen; Wong, Elissa Wp et al. (2018) COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. J Clin Invest 128:1442-1457
Singhal, Udit; Wang, Yugang; Henderson, James et al. (2018) Multigene Profiling of CTCs in mCRPC Identifies a Clinically Relevant Prognostic Signature. Mol Cancer Res 16:643-654
Wang, Xiaoju; Qiao, Yuanyuan; Asangani, Irfan A et al. (2017) Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer. Cancer Cell 31:532-548.e7
Blattner, Mirjam; Liu, Deli; Robinson, Brian D et al. (2017) SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell 31:436-451
Dai, Xiangpeng; Gan, Wenjian; Li, Xiaoning et al. (2017) Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med 23:1063-1071
Lin, Ke-Chih; Torga, Gonzalo; Wu, Amy et al. (2017) Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg Sci Phys Oncol 3:
Lange, Ethan M; Ribado, Jessica V; Zuhlke, Kimberly A et al. (2016) Assessing the Cumulative Contribution of New and Established Common Genetic Risk Factors to Early-Onset Prostate Cancer. Cancer Epidemiol Biomarkers Prev 25:766-72
Roychowdhury, Sameek; Chinnaiyan, Arul M (2016) Translating cancer genomes and transcriptomes for precision oncology. CA Cancer J Clin 66:75-88
Chen, Weiqiang; Allen, Steven G; Reka, Ajaya Kumar et al. (2016) Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics. BMC Cancer 16:614

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