The Developmental Research Program is designed to provide funding to initiate promising translational studies with a focus on head and neck cancer. High priority will be given to projects that will generate clinically-relevant hypotheses aimed at reducing the incidence, morbidity or mortality of head and neck cancer or improving the quality of life of patients with head and neck cancer. At least annually, proposals for innovative translational research in head and neck cancer will be solicited throughout all institutions in the Texas Medical Center. It is anticipated that some applicants will be without extensive experience in preparing successful research proposals; therefore, the Director and Co-Director will help investigators formulate specific aims and research plans that are translational in nature, with realistic and appropriate budgets. Thus, in addition to developing promising research projects for the SPORE program, the Developmental Research Program also will be a major educational activity that will further enhance the initiation and development of innovative translational research concepts in head and neck cancer. The SPORE Executive Committee will screen proposals for appropriate SPORE qualifications using objective criteria. The selected proposals then will undergo scientific review and prioritization by members of the SPORE External Scientific Advisory Board; final selection of the research projects to be funded will be made on the basis of these reviews. A two-year funding period will be allowed, with allocation of funds for the second year to be made after satisfactory review of a thorough progress report from the awardee. Additional funding may be granted if it is felt that an additional year of work will lead to independent peer-reviewed funding and/or lead to significant enhancement in treatment or prevention of head and neck cancer; requests for this additional funding will be very carefully reviewed by the SPORE Executive Committee and External Scientific Advisory Board. As part of our continuing efforts to expand head and neck cancer research at M.D. Anderson Cancer Center and in anticipation of this SPORE application, developmental research projects were solicited within our institution in early 2001; the four projects considered to be of highest potential and consistent with the translational focus of the SPORE are included here and represent those that will be reviewed for funding consideration to begin in Year 1 of the SPORE program. These projects illustrate the breadth and depth of interest in head and neck cancer translational research at our institution.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA097007-01
Application #
6693233
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-09-30
Project End
2007-07-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Zhang, Hua; Sturgis, Erich; Zhu, Lijun et al. (2018) The Modifying Effect of a Functional Variant at the miRNA Binding Site in E2F1 Gene on Recurrence of Oropharyngeal Cancer Patients with Definitive Radiotherapy. Transl Oncol 11:633-638
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
(2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50:668-681
Jurkovic, Ines-Ana; Kocak-Uzel, Esengul; Mohamed, Abdallah Sherif Radwan et al. (2018) Dosimetric and Radiobiological Evaluation of Patient Setup Accuracy in Head-and-neck Radiotherapy Using Daily Computed Tomography-on-rails-based Corrections. J Med Phys 43:28-40
Huckins, L M; Hatzikotoulas, K; Southam, L et al. (2018) Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Mol Psychiatry 23:1169-1180
M. D. Anderson Cancer Center Head and Neck Quantitative Imaging Working Group (2018) Investigation of radiomic signatures for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients. Sci Rep 8:1524
Gadhikar, Mayur A; Zhang, Jiexin; Shen, Li et al. (2018) CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res 78:781-797
Zhang, Tongwu; Choi, Jiyeon; Kovacs, Michael A et al. (2018) Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Res 28:1621-1635
Saintigny, Pierre; Mitani, Yoshitsugu; Pytynia, Kristen B et al. (2018) Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Cancer 124:3693-3705
Pinnix, Chelsea C; Ng, Andrea K; Dabaja, Bouthaina S et al. (2018) Positron emission tomography-computed tomography predictors of progression after DA-R-EPOCH for PMBCL. Blood Adv 2:1334-1343

Showing the most recent 10 out of 370 publications