This competitive renewal application for a Specialized Program of Research Excellence (SPORE) in Cervical Cancer at Johns Hopkins University School of Medicine, University of Alabama at Birmingham, University of Colorado and our new collaborator Mount Sinai Icahn School of Medicine brings together a highly interactive, multidisciplinary, and inter-institutional program of translational research in cervical cancer. Th SPORE includes five integrated projects spanning the fields of prevention and treatment cervical cancer and its precursor lesions. Project 1: L1 capsomeres as a next generation preventive HPV vaccine, led by Robert Garcea, M.D. and Warner Huh, M.D. Project 2: Local vaccination and imiquimod for persistent HPV16+ patients with normal cytology, led by Richard Roden, Ph.D., Warner Huh, M.D. and T.-C. Wu, M.D., Ph.D. Project 3: Treatment of HIV- and HIV+ patients with CIN2/3 using an HPV DNA vaccine administered intramuscularly via electroporation, led by Ronald Alvarez, M.D., Chien-Fu Hung, Ph.D. and Richard Roden, Ph.D. Project 4: Molecular attributes of tissue immune response in HPV disease, led by Cornelia Trimble, M.D. and Michael Donovan, M.D., Ph.D. Project 5: Safety and immunogenicity study of a HPV16-specific therapeutic protein administered intratumorally during chemoradiation, led by Ronald Alvarez, M.D., Richard Roden, Ph.D. and T.-C. Wu, M.D., Ph.D. The five integrated projects are supported by three cores that provide critical supportive infrastructure essential to efficient and effective translational research: the Administrative/Communication Core (Core A), led by T.-C. Wu, M.D., Ph.D. and Edward Partridge, M.D., the Biostatistics/Data Management Core (Core B), led by Sejong Bae Ph.D., Karan Singh, Ph.D., and Chenguang Wang, Ph.D. and the Tissue/Pathology and Immunology Core (Core C), led by Cornelia Trimble, M.D. and Lawrence Lamb, Ph.D. The SPORE also includes a Developmental Research Program (led by T.- C. Wu, M.D., Ph.D. and Drew Pardoll M.D., Ph.D.) to nurture novel research ideas and technologies and a Career Development Program (led by T.-C. Wu, M.D., Ph.D. and Edward Partridge, M.D.) to recruit and facilitate career development of individuals with interest in translational cervical cancer research.

Public Health Relevance

This research program provides a spectrum of capabilities, driving innovative translational research for improved prevention and treatment of cervical cancer to better patient outcomes and our understanding of cancer biology and immunology

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA098252-11
Application #
8740662
Study Section
Special Emphasis Panel (ZCA1-RPRB-C (M1))
Program Officer
Kuzmin, Igor A
Project Start
2003-09-30
Project End
2019-08-31
Budget Start
2014-09-24
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
$2,162,000
Indirect Cost
$493,605
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wang, Joshua W; Wu, Wai Hong; Huang, Tsui-Chin et al. (2018) Roles of Fc Domain and Exudation in L2 Antibody-Mediated Protection against Human Papillomavirus. J Virol 92:
Bywaters, S M; Brendle, S A; Biryukov, J et al. (2018) Production and characterization of a novel HPV anti-L2 monoclonal antibody panel. Virology 524:106-113
Powell, T Clark; Dilley, Sarah E; Bae, Sejong et al. (2018) The Impact of Racial, Geographic, and Socioeconomic Risk Factors on the Development of Advanced-Stage Cervical Cancer. J Low Genit Tract Dis 22:269-273
Cheng, Max A; Farmer, Emily; Huang, Claire et al. (2018) Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases. Hum Gene Ther 29:971-996
Lin, Yi-Hsin; Yang, Ming-Chieh; Tseng, Ssu-Hsueh et al. (2018) Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control. Cancer Immunol Res :
Boitano, Teresa K L; Smith, Haller J; Rushton, Tullia et al. (2018) Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecol Oncol 151:282-286
Anchoori, Ravi K; Jiang, Rosie; Peng, Shiwen et al. (2018) Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer. ACS Omega 3:11917-11929
Ooki, Akira; Dinalankara, Wikum; Marchionni, Luigi et al. (2018) Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma. Oncogene 37:5967-5981
Ahn, Julie; Bishop, Justin A; Roden, Richard B S et al. (2018) The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. Laryngoscope 128:E27-E32
Silver, Michelle I; Rositch, Anne F; Phelan-Emrick, Darcy F et al. (2018) Uptake of HPV testing and extended cervical cancer screening intervals following cytology alone and Pap/HPV cotesting in women aged 30-65 years. Cancer Causes Control 29:43-50

Showing the most recent 10 out of 291 publications