The incidence of type 2 diabetes mellitus is on the rise to the extent that diabetes rapid and widespread nature has been referred to as pandemic in the United States;type 1 diabetes is also increasing at an unexpected rate. As such, there is an urgent need for innovative therapeutics and technologies to deal with this situation, and hence a need to train a cadre of future scientists who can engineer devices and therapeutics with in-depth knowledge and training to link their research to clinical care to address the prevention and treatment of diabetes. The Indiana Bioengineering Interdisciplinary Training for Diabetes Research program was conceived to meet this need. A novel and notable aspect of our program is the interaction and integration of premier faculty of the Weldon School of Biomedical Engineering at Purdue University with the exceptional diabetes research faculty of the Indiana University School of Medicine, providing and elite training experience for future bioengineer-diabetologists. This educational model has already proven feasibility, by virtue of the successes of our Indiana MSTP T32 and our Indiana CTSI training programs.
The aim of the Indiana Bioengineering Interdisciplinary Training for Diabetes Research program is to provide interdisciplinary, integrated research training to develop predoctoral students into bioengineers capable of leading integrative and team-based approaches to solve issues relevant to the understanding, prevention and treatment of diabetes and diabetic complications. This unique and integrated format benefits from co-directorship by each institutional program using the multi-PI mechanism, with Dr. A. Panitch (Biomedical engineering PI, Purdue University) and Dr. D. Thurmond (Diabetes research PI, Indiana University School of Medicine) coordinating a select group of exemplary bioengineering and diabetes-based research faculties to co-mentor our students, in combination with a carefully designed flexible curriculum that provides in-depth training for students in engineering relevant to diabetes. Our program emphasizes coursework that broadens research training at the bench with quantitative skills, provides opportunities for public speaking, provides a range of enriching extracurricular opportunities, and allows for integration of medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of trainees throughout the program. By training in an environment and culture that gives strong interdisciplinary support for bioengineering and diabetes research, there is a significant probability that the bioengineering trainees will sustain an interest in diabetes, even as their specific research interests evolve over their careers.

Public Health Relevance

The incidence of type 2, as well as type 1, diabetes mellitus is on the increase to the extent that diabetes has become a major health concern in the United States, thus requiring innovative therapeutics and technologies to deal with this situation. As a result, there is a need to train a cadre of future scientists who can engineer devices and therapeutics with in-depth knowledge and training to link their research to clinical care to address the prevention and treatment of diabetes. The Purdue University BME-Indiana University Medical School diabetes research training program was conceived to meet this need.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
1T32DK101001-01
Application #
8633211
Study Section
Special Emphasis Panel (ZDK1-GRB-G (O4))
Program Officer
Castle, Arthur
Project Start
2013-09-04
Project End
2018-09-03
Budget Start
2013-09-04
Budget End
2014-09-03
Support Year
1
Fiscal Year
2013
Total Cost
$45,411
Indirect Cost
$2,179
Name
Purdue University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Soepriatna, Arvin H; Damen, Frederick W; Vlachos, Pavlos P et al. (2018) Cardiac and respiratory-gated volumetric murine ultrasound. Int J Cardiovasc Imaging 34:713-724
Sangha, Gurneet S; Hale, Nicholas J; Goergen, Craig J (2018) Adjustable photoacoustic tomography probe improves light delivery and image quality. Photoacoustics 12:6-13
Damen, Frederick W; Berman, Alycia G; Soepriatna, Arvin H et al. (2017) High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function. Tomography 3:180-187
Ghosh, Soham; Cimino, James G; Scott, Adrienne K et al. (2017) In Vivo Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle. ACS Biomater Sci Eng 3:2798-2805
McMasters, James; Poh, Scott; Lin, Jenny B et al. (2017) Delivery of anti-inflammatory peptides from hollow PEGylated poly(NIPAM) nanoparticles reduces inflammation in an ex vivo osteoarthritis model. J Control Release 258:161-170
Sangha, Gurneet S; Phillips, Evan H; Goergen, Craig J (2017) In vivo photoacoustic lipid imaging in mice using the second near-infrared window. Biomed Opt Express 8:736-742
Wodicka, James R; Chambers, Andrea M; Sangha, Gurneet S et al. (2017) Development of a Glycosaminoglycan Derived, Selectin Targeting Anti-Adhesive Coating to Treat Endothelial Cell Dysfunction. Pharmaceuticals (Basel) 10:
Goodwill, Adam G; Dick, Gregory M; Kiel, Alexander M et al. (2017) Regulation of Coronary Blood Flow. Compr Physiol 7:321-382
Pereyra, Andrea S; Hasek, Like Y; Harris, Kate L et al. (2017) Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy. J Biol Chem 292:18443-18456
Lin, Jenny B; Poh, Scott; Panitch, Alyssa (2016) Controlled release of anti-inflammatory peptides from reducible thermosensitive nanoparticles suppresses cartilage inflammation. Nanomedicine 12:2095-2100

Showing the most recent 10 out of 14 publications