The goal of this project is to investigate the effects of lexical and syntactic factors in sentence production in aphasia. Lexical factors will be divided into those associated with nouns (noun-related semantics), and those associated with verbs (verb argument structure). Syntactic effects to be explored are those associated with word orders that place the agent/actor of a verb before or after the verb (constituent order). The role that these factors play in determining sentence production will be examined for normal subjects and aphasic patients, using a series of different tasks designed to provide converging evidence regarding aphasic patients' performances. These factors will be used as independent variables in experiments in which the ability to produce lexical items, grammatical elements, syntactic structures, and thematic roles will be the dependent measures. The research is designed to provide basic data regarding sentence production in aphasia that is not presently available. These data will related to models of normal sentence production. They may ultimately be useful in guiding therapy directed at improving aphasic patients' sentence production abilities.

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Boston University
United States
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Zeng, Yong; Petralia, Ronald S; Vijayasarathy, Camasamudram et al. (2016) Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography. Invest Ophthalmol Vis Sci 57:OCT277-87
Kurowski, Kathleen; Blumstein, Sheila E (2016) Phonetic basis of phonemic paraphasias in aphasia: Evidence for cascading activation. Cortex 75:193-203
Mirman, Daniel; Yee, Eiling; Blumstein, Sheila E et al. (2011) Theories of spoken word recognition deficits in aphasia: evidence from eye-tracking and computational modeling. Brain Lang 117:53-68
Myung, Jong-yoon; Blumstein, Sheila E; Yee, Eiling et al. (2010) Impaired access to manipulation features in Apraxia: evidence from eyetracking and semantic judgment tasks. Brain Lang 112:101-12
Kurowski, Kathleen M; Blumstein, Sheila E; Palumbo, Carole L et al. (2007) Nasal consonant production in Broca's and Wernicke's aphasics: speech deficits and neuroanatomical correlates. Brain Lang 100:262-75
Connor, L (2001) Memory in old age: patterns of decline and preservation. Semin Speech Lang 22:117-25