Papillomas of the upper respiratory tract are caused by human papillomaviruses (HPVs). These histologically benign tumors cause a high degree of morbidity and significant mortality. The objective of this Clinical Research Center application is to focus a multidisciplinary approach to this disease. The program consists of an interactive working group of basic scientists and clinicians, sharing their expertise to study aspects of the papillomas ranging from the viral molecule to the infected individual. Through the interactions of this group, insights are provided into mechanisms of pathogenesis and therapeutic response that would not exist if either basic science or clinical studies alone were done. Persistence and expression of the HPV DNA and subsequent host response are recurrent sub-themes of this project. From these studies, we will develop a base of knowledge that will lead to better ways to cure or control respiratory papillomas. The projects within this program are: 1. Study the regulation of the early HPV promoters, and determine whether epidermal growth factor, a key regulator of the papilloma phenotype, alters transcription. 2. Determine the efficacy of a new photosensitizer for photodynamic therapy, and determine why only some patients respond to this therapy. 3. Study interactions between the HPV regulatory region and tissue factors in the control of viral expression and replication. 4. Study the effects of antisense oligonucleotides on HPV DNA persistence, and establish the background data for possible future therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
2P50DC000203-15A1
Application #
2835542
Study Section
Special Emphasis Panel (ZDC1-SRB-S (01))
Project Start
1983-08-01
Project End
2004-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Long Island Jewish Medical Center
Department
Type
DUNS #
City
New Hyde Park
State
NY
Country
United States
Zip Code
11040
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Abramson, Allan L; Nouri, May; Mullooly, Virginia et al. (2004) Latent Human Papillomavirus infection is comparable in the larynx and trachea. J Med Virol 72:473-7
Vambutas, Andrea; Bonagura, Vincent R; Reed, Elaine F et al. (2004) Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11. J Infect Dis 189:871-9

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