This Clinical Research Center (P50) proposal is focused on providing a neuroimaging-based examination of language recovery in individuals with chronic aphasia resulting from stroke. The goal of the Center is to bring together the expertise of clinical investigators with mutual scientific interest and complementary expertise in understanding the cognitive and neural correlates of stroke-induced language recovery, the effects of language treatment on these processes, and cognitive and neural factors (biomarkers) of language/brain recovery. The proposal includes three subprojects, which examine language recovery in three language domains, with experts in each serving as PI: Subproject 1. The neurobiology of recovery of spoken naming in aphasia, Swathi Kiran (Boston University) and David Caplan (Harvard, MGH);Subproject 2. The neurobiology of recovery of written naming in acquired dysgraphia, Brenda Rapp (Johns Hopkins);and Subproject 3. The neurobiology of recovery of sentence processing in agrammatism, Cynthia Thompson (Northwestern). Combining the expertise and efforts of the PIs on this project will allow us to study aphasia recovery in a comprehensive manner. At the heart of the approach is a common set of cognitive and neuroimaging measures, including functional magnetic resonance imaging (fMRI), structural and perfusion imaging, and diffusion tensor imaging (DTI), which we will use as tools for identifying, monitoring and evaluating cognitive-brain changes at several time points, coinciding with treatment application and spanning a one-year period. Cross-project data will be deposited into a centralized Neuroimaging and Data Analysis Core (Core B) where they will be analyzed by an expert team of neuroimaging specialists and statisticians, led by Todd Parnsh (PI;neurophysicist at Northwestern), using state-of-the art neuroimaging acquisition and analysis methods. This will allow us to examine the effects of treatment designed to improve specific aphasic language deficits and to answer questions relevant to the relation between language and brain variables and treatment-induced versus natural recovery in chronic aphasia. The work will highly impact clinical intervention practices for individuals with aphasia, providing importan information relevant to the effects of treatment and prognosis for recovery, and contribute to knowledge about brain plasticity and the reorganization of language functions in the adult brain.

Public Health Relevance

Understanding the neurobiology of language recovery in stroke-induced language impairment (aphasia) is critical for advancing clinical practice for this devastating disorder. The comprehensive, innovative and theoretically grounded set of experiments examining how treatment impacts recovery coupled with state-of-the- art neuroimaging methodology that will be used in this Clinical Research Center are expected to significantly move forward our understanding of the effects of treatment on the stroke-recovering brain and the cognitive and neural factors that affect it, enhancing the ability to provide accurat prognosis for recovery and prescribe effect treatment. Subproject 1 The Neurobiology of Recovery of Naming Impairments Lead Investigators: Swathi Kiran &David Caplan

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Specialized Center (P50)
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Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Cooper, Judith
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Northwestern University at Chicago
Other Health Professions
Schools of Arts and Sciences
United States
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Gilmore, Natalie; Meier, Erin L; Johnson, Jeffrey P et al. (2018) Typicality-based semantic treatment for anomia results in multiple levels of generalisation. Neuropsychol Rehabil :1-27
Purcell, Jeremy J; Rapp, Brenda (2018) Local response heterogeneity indexes experience-based neural differentiation in reading. Neuroimage 183:200-211
Meier, Erin L; Johnson, Jeffrey P; Kiran, Swathi (2018) Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls. Cortex 108:173-192
Mack, Jennifer E; Thompson, Cynthia K (2017) Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms. J Speech Lang Hear Res 60:1299-1315
Rothlein, David; Rapp, Brenda (2017) The role of allograph representations in font-invariant letter identification. J Exp Psychol Hum Percept Perform 43:1411-1429
Meier, Erin L; Johnson, Jeffrey P; Villard, Sarah et al. (2017) Does Naming Therapy Make Ordering in a Restaurant Easier? Dynamics of Co-Occurring Change in Cognitive-Linguistic and Functional Communication Skills in Aphasia. Am J Speech Lang Pathol 26:266-280
Mack, Jennifer E; Nerantzini, Michaela; Thompson, Cynthia K (2017) Recovery of Sentence Production Processes Following Language Treatment in Aphasia: Evidence from Eyetracking. Front Hum Neurosci 11:101
Thompson, Cynthia K; Walenski, Matthew; Chen, YuFen et al. (2017) Intrahemispheric Perfusion in Chronic Stroke-Induced Aphasia. Neural Plast 2017:2361691
Schuchard, Julia; Thompson, Cynthia K (2017) Sequential learning in individuals with agrammatic aphasia: evidence from artificial grammar learning. J Cogn Psychol (Hove) 29:521-534
Schuchard, Julia; Nerantzini, Michaela; Thompson, Cynthia K (2017) Implicit learning and implicit treatment outcomes in individuals with aphasia. Aphasiology 31:25-48

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