Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
1P50DE007118-01
Application #
4692839
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Brogan, J M; Lally, E T; Poulsen, K et al. (1994) Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect Immun 62:501-8
DiRienzo, J M; McKay, T L (1994) Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity. J Clin Microbiol 32:75-81
DiRienzo, J M; Slots, J; Sixou, M et al. (1994) Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis. Infect Immun 62:3058-65
Lally, E T; Golub, E E; Kieba, I R (1994) Identification and immunological characterization of the domain of Actinobacillus actinomycetemcomitans leukotoxin that determines its specificity for human target cells. J Biol Chem 269:31289-95
Shenker, B J; Vitale, L A; Keiba, I et al. (1994) Flow cytometric analysis of the cytotoxic effects of Actinobacillus actinomycetemcomitans leukotoxin on human natural killer cells. J Leukoc Biol 55:153-60
Shenker, B J; Wannberg, S; Vitale, L et al. (1993) Reconstruction of severe combined immunodeficient mice with lymphocytes from patients with localized juvenile periodontitis. J Periodontal Res 28:487-90
Berthold, P; Forti, D; Kieba, I R et al. (1992) Electron immunocytochemical localization of Actinobacillus actinomycetemcomitans leukotoxin. Oral Microbiol Immunol 7:24-7
Lally, E T; Golub, E E; Kieba, I R et al. (1991) Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex. Microb Pathog 11:111-21
Taichman, N S; Iwase, M; Korchak, H et al. (1991) Membranolytic activity of Actinobacillus actinomycetemcomitans leukotoxin. J Periodontal Res 26:258-60
Shenker, B J; Vitale, L; Slots, J (1991) Immunosuppressive effects of Prevotella intermedia on in vitro human lymphocyte activation. Infect Immun 59:4583-9

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