The Orofacial Pain Research Center will be a collaborative effort between researchers in the UCLA School of Dentistry and the UCLA School of Medicine. The Center will be based in the Dental Research Institute (DRI) at the UCLA School of Dentistry and will draw heavily upon the patients of the Temporomandibular and Facial Pain Clinic (TMFPC) in the School of Dentistry and the Pain Management Center (PMC) in the School of Medicine. The projects which involve human subjects will occur within the UCLA DRI's Clinical Research Center (CRC) whenever possible. This application contains five research projects that test a number of hypotheses around the central theme of orofacial pain research. One of these projects involve an animal model. This project is on herpes simplex virus and its effect on trigeminal nerve function in guinea pigs. Two other projects will involve research on the diagnosis, etiology or underlying mechanisms of various orofacial pain problems in human subjects. One is a study of the significance of temporomandibular tomograms in the diagnostic process for temporomandibular disorder patients. Another is an evaluation of masticatory muscle activity patterns (both ambulatory and sleeping) in patients diagnosed with chronic headaches. Finally, there are two studies on the treatment of orofacial pain problems. One is a study of the effectiveness of two commonly used medications (antidepressants and neuroleptics for the treatment of chronic post-herpetic neuralgia. The other is a study involving the assessment of various psychological factors as a method of predicting which TM disorder patients will improve with conventional physical medicine treatment. The second part of this study will involve the evaluation of patients who do not significantly improve with the above treatment regime. It will compare the effectiveness of two psychological treatments to a waiting list control group.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Specialized Center (P50)
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University of California Los Angeles
Schools of Dentistry/Oral Hygn
Los Angeles
United States
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Seligman, D A; Pullinger, A G (2006) Dental attrition models predicting temporomandibular joint disease or masticatory muscle pain versus asymptomatic controls. J Oral Rehabil 33:789-99
Seligman, Donald A; Pullinger, Andrew G (2004) Improved interaction models of temporomandibular joint anatomic relationships in asymptomatic subjects and patients with disc displacement with or without reduction. J Orofac Pain 18:192-202
Reeves 2nd, John L; Graff-Radford, Steven B; Shipman, Diana (2004) The effects of transcutaneous electrical nerve stimulation on experimental pain and sympathetic nervous system response. Pain Med 5:150-61
Pullinger, Andrew G; Seligman, Donald A; John, Mike T et al. (2002) Multifactorial modeling of temporomandibular anatomic and orthopedic relationships in normal versus undifferentiated disk displacement joints. J Prosthet Dent 87:289-97
Pullinger, Andrew G; Seligman, Donald A; John, Mike T et al. (2002) Multifactorial comparison of disk displacement with and without reduction to normals according to temporomandibular joint hard tissue anatomic relationships. J Prosthet Dent 87:298-310
Pullinger, A G; Seligman, D A (2001) Multifactorial analysis of differences in temporomandibular joint hard tissue anatomic relationships between disk displacement with and without reduction in women. J Prosthet Dent 86:407-19
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Pullinger, A G; White, S C (1995) Efficacy of TMJ radiographs in terms of expected versus actual findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:367-74
Clark, G T; Sakai, S; Merrill, R et al. (1995) Cross-correlation between stress, pain, physical activity, and temporalis muscle EMG in tension-type headache. Cephalalgia 15:511-8, discussion 451

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