The research projects conducted by the Oral Cancer Research Center will utilize tissue samples from a common pool of patients. Tissues will be stored in a common tissue bank. This centralization facilitates the provision of common management information and statistical consulting services. Preliminary calculations showed that the projected tissue accrual will yield acceptable statistical power even if only a small fraction of the patients can provide useable data on any given project. Specifically, 300 useable patients out of a total projected accrual of 1,500 would yield a power of at least 80% to detect clinical effects observed in other studies of integrins and proteinases. A computerized data base will be designed, implemented and maintained. The data base will allow tracking of patient demographic and clinical information and information derived from tissue samples. Biostatistical consulting will be provided on an individualized basis to the research projects. The primary endpoint will be disease-free survival, but marker status will also be correlated with clinical stage and other variables of interest. In addition, the results of the individual research projects will be integrated using multivariate statistical techniques. This will allow for the estimation of the simultaneous effect of different markers and may serve to derive risk scores for future clinical use.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
3P50DE011912-03S1
Application #
6104933
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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