This is a new George O'Brien Kidney Research Center application from the Albert Einstein College of Medicine (AECOM. The theme of this application, """"""""Cell Signaling in the Kidney"""""""", recognizes both the broad array of cellular signaling that characterizes the normal kidney as well as the critical role of cell signaling in pathological conditions. Six investigators propose highly interactive projects aimed at understanding signaling in the normal and diseased glomerulus. In the broadest sense, i this application seeks to: 1) Provide an infrastructure that enhances progress in kidney disease-related research, and facilitates translating the results of research into improved care for people with renal disease. Specifically, this will be accomplished by supporting four sub-programs for five years each and two Developmental Research/Pilot and Feasibility Study sub-programs for two years each; 2) Provide an ongoing Developmental Research/Pilot and Feasibility Study Program over five years that supports initiation of new research programs in renal-related areas that are both basic and translational; 3) Provide an Administrative Core as the principal means of planning, implementing, and monitoring the programs in research and training; 4) Provide an Imaging Core that serves the linked needs of all O'Brien investigators in this technical area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK064236-03
Application #
6897828
Study Section
Special Emphasis Panel (ZDK1-GRB-D (J1))
Program Officer
Moxey-Mims, Marva M
Project Start
2003-06-01
Project End
2008-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
3
Fiscal Year
2005
Total Cost
$1,169,000
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Chi, Yuling; Suadicani, Sylvia O; Schuster, Victor L (2014) Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharmacol Res Perspect 2:e00051
Veron, Delma; Villegas, Guillermo; Aggarwal, Pardeep Kumar et al. (2012) Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus. PLoS One 7:e40589
Veron, D; Bertuccio, C A; Marlier, A et al. (2011) Podocyte vascular endothelial growth factor (Vegf???) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 54:1227-41
Chi, Yuling; Min, Jaeki; Jasmin, Jean-Francois et al. (2011) Development of a high-affinity inhibitor of the prostaglandin transporter. J Pharmacol Exp Ther 339:633-41
Chi, Yuling; Schuster, Victor L (2010) The prostaglandin transporter PGT transports PGH(2). Biochem Biophys Res Commun 395:168-72
Chang, Hee-Yoon; Locker, Joseph; Lu, Run et al. (2010) Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation 121:529-36
Veron, Delma; Reidy, Kimberly J; Bertuccio, Claudia et al. (2010) Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease. Kidney Int 77:989-99
Veron, Delma; Reidy, Kimberly; Marlier, Arnaud et al. (2010) Induction of podocyte VEGF164 overexpression at different stages of development causes congenital nephrosis or steroid-resistant nephrotic syndrome. Am J Pathol 177:2225-33
Reidy, Kimberly J; Villegas, Guillermo; Teichman, Jason et al. (2009) Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development. Development 136:3979-89
Wei, Changli; Moller, Clemens C; Altintas, Mehmet M et al. (2008) Modification of kidney barrier function by the urokinase receptor. Nat Med 14:55-63

Showing the most recent 10 out of 34 publications