The Biostatistics Core provides support to the 3 projects of the O'Brien Center in the areas of study design, data collection and visualization, database development and management, data quality control, data analysis, bioinformatics, and interpretation. In this regard, members ofthe Core provide solutions to commonplace and complex or unique problems that arise during the planning and execution of the projects. Core investigators have extensive experience in a wide range of biostatistical, epidemiologic and translational research methodologies and applications. This O'Brien Center focuses on the epidemiology, genetics, biomarkers, and treatment of benign prostatic hyperplasia (BPH). Each project has extensive discussion with a biostatistician/epidemiologist whose own primary research focus is prostatic diseases. Because Core members already have considerable understanding of many of the central research questions and research problems associated with prostatic diseases, they are able to play an integral role as members of the team for each project, and serve as a bridge to facilitate interactions among the projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK082998-02
Application #
8132350
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$64,074
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Na, Rong; Helfand, Brian T; Chen, Haitao et al. (2017) A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate 77:1213-1220
Kulac, Ibrahim; Gumuskaya, Berrak; Drake, Charles G et al. (2016) Peripheral Zone Inflammation Is Not Strongly Associated With Lower Urinary Tract Symptom Incidence and Progression in the Placebo Arm of the Prostate Cancer Prevention Trial?. Prostate 76:1399-408
Torkko, Kathleen C; Wilson, R Storey; Smith, Elizabeth E et al. (2015) Prostate Biopsy Markers of Inflammation are Associated with Risk of Clinical Progression of Benign Prostatic Hyperplasia: Findings from the MTOPS Study. J Urol 194:454-61
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2014) A prospective study of obesity, and the incidence and progression of lower urinary tract symptoms. J Urol 191:715-21
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2013) A prospective study of statin drug use and lower urinary tract symptoms in older men. Am J Epidemiol 178:797-803
Platz, Elizabeth A; Joshu, Corinne E; Mondul, Alison M et al. (2012) Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States men. J Urol 188:496-501
Mooney, Steven M; Rajagopalan, Krithika; Williams, Brenten H et al. (2011) Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses. J Cell Biochem 112:1066-75
Rajagopalan, Krithika; Mooney, Steven M; Parekh, Nehal et al. (2011) A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem 112:3256-67
Zeng, Yu; He, Yanan; Yang, Fan et al. (2011) The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem 286:13985-94