The past 25 years of research under this Center grant have solidified the observations 1) that under hypoxic conditions, many processes of wound healing cannot proceed normally, particularly resistance to infection, collagen synthesis, angiogenesis, and inflammation; 2) that these processes, in fact, work more efficiently at supraphysiologic oxygen concentrations; and 3) that hypoxic conditions are the norm in injured tissue and in trauma patients. These observations lead inescapably to the conclusion that one of the most critical aspects of the care of traumatized patients is maintenance of oxygen delivery to injured tissues. This requires high flow of blood at high PO2 but not necessarily high oxygen content. Physician estimates of peripheral perfusion are usually inaccurate (usually overestimates); therefore, this goal cannot be achieved unless tissue oxygen is measured.
The aim of the current proposal is to convert tissue oximetry from a research tool to a clinical monitor, by identifying means to remove obstacles to perfusion, and by demonstrating that use of these means combined with PO2 monitoring in the ICU setting leads to improved patient outcome.
| Gimbel, Michael L; Rollins, Mark D; Fukaya, Eri et al. (2009) Monitoring partial and full venous outflow compromise in a rabbit skin flap model. Plast Reconstr Surg 124:796-803 |
| Ogino, Tetsuya; Than, Tin Aung; Hosako, Mutsumi et al. (2009) Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol 643:451-61 |
| Hunt, Thomas K; Aslam, Rummana S; Beckert, Stefan et al. (2007) Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal 9:1115-24 |
| Hansen, Scott L; Dosanjh, Amarjit; Young, David M et al. (2006) Hemangiomas and homeobox gene expression. J Craniofac Surg 17:767-71 |
| Rosen, Noah A; Hopf, Harriet W; Hunt, Thomas K (2006) Perflubron emulsion increases subcutaneous tissue oxygen tension in rats. Wound Repair Regen 14:55-60 |
| Hopf, Harriet W; Gibson, Jeffrey J; Angeles, Adam P et al. (2005) Hyperoxia and angiogenesis. Wound Repair Regen 13:558-64 |
| Fries, Richard B; Wallace, William A; Roy, Sashwati et al. (2005) Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res 579:172-81 |
| Hansen, Scott L; Myers, Connie A; Charboneau, Aubri et al. (2003) HoxD3 accelerates wound healing in diabetic mice. Am J Pathol 163:2421-31 |
| Hansen, Scott L; Young, David M; Boudreau, Nancy J (2003) HoxD3 expression and collagen synthesis in diabetic fibroblasts. Wound Repair Regen 11:474-80 |
| Trabold, Odilo; Wagner, Silvia; Wicke, Corinna et al. (2003) Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen 11:504-9 |
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