This Specialized Center of Research will continue to provide a central supporting structure for the efforts of many investigators concerned with the pulmonary problems of cystic fibrosis and provide a forum for integration and cooperation between their individual projects. The primary topic of the SCOR is being addressed by both clinical and basic research projects. The former are attempting to find better means of patient care and more sensitive indicators of disease progression while the latter are studying the pathologic mechanisms of lung injury and the basic metabolic defect. The specific goals of the individual projects are: To use a centralized patient data base and analysis system to coordinate patient care and research studies To demonstrate the feasibility and medical effectiveness of using automated analysis of home measurements for improving clinical care To continue the evolution of a new pulmonary function test for patients of all ages and to use this test to follow normal lung development in young children and disease progression in CF patients. To investigate the structure and function of mucopolysaccharide molecules in bronchial mucus. To evaluate a possible mechanism of CF lung destruction by pulmonary macrophages and continue investigations of their metabolic, structural and phagocytic properties. To expand upon observations of enhanced metabolic activities of CF monocytes To extend the knowledge of the deranged NADH dehydrogenase found in mitochondria from CF subjects as a probable basic defect in CF cells and investigate the possibility of a prenatal test for CF.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL027355-04
Application #
3106648
Study Section
(SRC)
Project Start
1982-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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