Abstract

Goals: The Laboratory/Morphology Core provides high quality and consistent support for all of the SCOR investigators who need common methods for analyzing fluids and tissues. The concept of the Laboratory/Morphology Core represents the most economical and efficient use of space, equipment, and skilled personnel. This core has a strong track record of productive and productive interactions with each of the components of the SCOR Program.
Specific Aims. Core C provides laboratory and morphology support for the projects in the SCOR Program.
The specific aims are: 1) To provide support for biochemical analyses in the SCOR BAL Program (Project 1). 2) To provide histological and morphological support for the SCOR BAL Program (Project 1) and the basic science projects (Projects 2-5). 3) To support interactions between the SCOR program and other collaborating laboratory groups in the United States and Europe in studying ARDS. 4) To facilitate specific studies related to Project 1 and the BAL program, such as investigating alternative ways to sample airspace fluids in patients with ARDS. Specific Methods. The specific methods available through Core C include cellular analyses, enzyme immunoassays, histology, electron microscopy, immunocytochemistry, in situ hybridization, and assays to detect cellular apoptosis and cell cycling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL030542-16
Application #
6109708
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Zimmerman, Jerry J; Akhtar, Saadia R; Caldwell, Ellen et al. (2009) Incidence and outcomes of pediatric acute lung injury. Pediatrics 124:87-95
Kurahashi, Kiyoyasu; Sawa, Teiji; Ota, Maria et al. (2009) Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 296:L198-209
Cooke, Colin R; Watkins, Timothy R; Kahn, Jeremy M et al. (2008) The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Crit Care 12:R134
Cooke, Colin R; Kahn, Jeremy M; Caldwell, Ellen et al. (2008) Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med 36:1412-20
Morris, Amy E; Stapleton, Renee D; Rubenfeld, Gordon D et al. (2007) The association between body mass index and clinical outcomes in acute lung injury. Chest 131:342-8
Kalhan, Ravi; Mikkelsen, Mark; Dedhiya, Pali et al. (2006) Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med 34:300-6
Stapleton, Renee D; Wang, Bennet M; Hudson, Leonard D et al. (2005) Causes and timing of death in patients with ARDS. Chest 128:525-32
Rubenfeld, Gordon D; Caldwell, Ellen; Peabody, Eve et al. (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685-93
Moriyama, Kiyoshi; Ishizaka, Akitoshi; Nakamura, Morio et al. (2004) Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol 286:L1114-21
Skerrett, Shawn J; Liggitt, H Denny; Hajjar, Adeline M et al. (2004) Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol 172:3377-81

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