Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD033727-01
Application #
2207253
Study Section
Special Emphasis Panel (ZRG5-IMS (01))
Project Start
1996-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Davis 3rd, Alvin E (2006) Mechanism of angioedema in first complement component inhibitor deficiency. Immunol Allergy Clin North Am 26:633-51
Cai, Shenghe; Dole, Vandana S; Bergmeier, Wolfgang et al. (2005) A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol 174:6462-6
Liu, Dongxu; Zhang, Dong; Scafidi, Jennifer et al. (2005) C1 inhibitor prevents Gram-negative bacterial lipopolysaccharide-induced vascular permeability. Blood 105:2350-5
Liu, Dongxu; Cramer, Cort C; Scafidi, Jennifer et al. (2005) N-linked glycosylation at Asn3 and the positively charged residues within the amino-terminal domain of the c1 inhibitor are required for interaction of the C1 Inhibitor with Salmonella enterica serovar typhimurium lipopolysaccharide and lipid A. Infect Immun 73:4478-87
Liu, Dongxu; Gu, Xiaogang; Scafidi, Jennifer et al. (2004) N-linked glycosylation is required for c1 inhibitor-mediated protection from endotoxin shock in mice. Infect Immun 72:1946-55
Cai, Shenghe; Davis 3rd, Alvin E (2003) Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion. J Immunol 171:4786-91
Liu, Dongxu; Cai, Shenghe; Gu, Xiaogang et al. (2003) C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide. J Immunol 171:2594-601
Han, Eun D; MacFarlane, Ryan C; Mulligan, Aideen N et al. (2002) Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 109:1057-63
Zahedi, Kamyar; Prada, Anne E; Mulligan, Aideen et al. (2002) Normal transcription of the C1 inhibitor gene is dependent upon a polypurine-polypyrimidine region within the promoter. Inflammation 26:183-91
Zahedi, R; MacFarlane, R C; Wisnieski, J J et al. (2001) C1 inhibitor: analysis of the role of amino acid residues within the reactive center loop in target protease recognition. J Immunol 167:1500-6

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