Abstract

The Clinical Epidemiology and Data Management Core supports projects utilizing clinical data or patient samples. The Core promotes interactions between investigators, providing the framework for a collaborative approach to answering clinically relevant questions about ALI/ARDS. Under the supervision of investigators, research nurses identify patients with ALI/ARDS or at risk for development of ALI/ARDS, enroll patients in bronchoalveolar lavage or other studies, and assist physician investigators with specimen collection. The data management team collects and enters patient data into the project database and performs statistical analyses requested by investigators. In addition, the Core provides statistical epidemiological and health services consultation to investigators including advice on study design, statistical power, construction of research hypotheses, data analysis, and interpretation of data. The Core team will build on fourteen years of experiences and existing screening and data abstraction protocols to expand the study population beyond Harborview Medical Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL030542-18
Application #
6430213
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
18
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Zimmerman, Jerry J; Akhtar, Saadia R; Caldwell, Ellen et al. (2009) Incidence and outcomes of pediatric acute lung injury. Pediatrics 124:87-95
Kurahashi, Kiyoyasu; Sawa, Teiji; Ota, Maria et al. (2009) Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 296:L198-209
Cooke, Colin R; Watkins, Timothy R; Kahn, Jeremy M et al. (2008) The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Crit Care 12:R134
Cooke, Colin R; Kahn, Jeremy M; Caldwell, Ellen et al. (2008) Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med 36:1412-20
Morris, Amy E; Stapleton, Renee D; Rubenfeld, Gordon D et al. (2007) The association between body mass index and clinical outcomes in acute lung injury. Chest 131:342-8
Kalhan, Ravi; Mikkelsen, Mark; Dedhiya, Pali et al. (2006) Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med 34:300-6
Rubenfeld, Gordon D; Caldwell, Ellen; Peabody, Eve et al. (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685-93
Stapleton, Renee D; Wang, Bennet M; Hudson, Leonard D et al. (2005) Causes and timing of death in patients with ARDS. Chest 128:525-32
Moriyama, Kiyoshi; Ishizaka, Akitoshi; Nakamura, Morio et al. (2004) Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol 286:L1114-21
Skerrett, Shawn J; Liggitt, H Denny; Hajjar, Adeline M et al. (2004) Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol 172:3377-81

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