The theme of this Specialized Center of Research (SCOR) in chronic disease of the airways is the role of hyperreactivity in chronic obstructive pulmonary disease (COPD). It is an interdisciplinary study bringing together basic scientists in immunology and physiology with clinical investigators in allergy and pulmonary medicine. The work proposed is an attempt to understand the connections between allergy, airways hyperreactivity, asthma, and COPD. The fundamental hypothesis on which the proposed work is based is that common to all forms of allergy, airways hyperreactivity, and asthma is the excessive release of chemical mediators from mast cells in a complex inflammatory process. Project I, The Response of the Nasal Mucosa to Hyperventilation with Cold, Dry Air, uses the human nose as a possible model of what is going on in the smaller airways that is responsible for the symptoms of asthma and COPD. Project II, Responses of the Lung Periphery to Dry Air and to Antigen, uses the peripheral airways of the dog to gain insight into what might be occurring in human airways disease. Project III, Relationship Between Mediators of Immediate Hypersensitivity and Cellular Inflammation in the Pathophysiology of Asthma and Obstructive Airways Disease, is concerned with inflammatory cells and mediators obtained from bronchoalveolar lavage in human subjects with and without airways hyperreactivity, asthma, and allergy. Project IV, Mechanism of the Antiasthmatic Action of Glucosteroids, uses antiinflammatory steroids to gain insight into the role of inflammation in allergy, airways hyperreactivity, and asthma. Project V, Human Basophil Activation by IgE-Dependent Factors, is a study of the effect of factors derived from the macrophage that cause mediator release from basophils and mast cells through IgE-dependent mechanisms. Core A, Mediator/Cell Core will characterize the inflammatory cells, and mediators for all of the projects. Core B, Administration, Clinical Physiology, and Data Management, will coordinate administration, data management, and statistical consultation for all of the projects and will recruit and characterize all human subjects used for clinical investigation.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Medicine
United States
Zip Code
Atweh, G F; Sutton, M; Nassif, I et al. (1999) Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood 93:1790-7
Fuller, S D; Freed, A N (1995) Partitioning of pulmonary function in rabbits during cholinergic stimulation. J Appl Physiol 78:1242-9
Freed, A N; Omori, C; Hubbard, W C et al. (1994) Dry air- and hypertonic aerosol-induced bronchoconstriction and cellular responses in the canine lung periphery. Eur Respir J 7:1308-16
Tang, G J; Freed, A N (1994) The role of submucosal oedema in increased peripheral airway resistance by intravenous volume loading in dogs. Eur Respir J 7:311-7
Baroody, F M; Majchel, A M; Roecker, M M et al. (1992) Ipratropium bromide (Atrovent nasal spray) reduces the nasal response to methacholine. J Allergy Clin Immunol 89:1065-75
Proud, D; Bailey, G S; Naclerio, R M et al. (1992) Tryptase and histamine as markers to evaluate mast cell activation during the responses to nasal challenge with allergen, cold, dry air, and hyperosmolar solutions. J Allergy Clin Immunol 89:1098-110
Tang, G J; Freed, A N (1992) The autonomic nervous system modulates dry air-induced constriction in the canine lung periphery. Am Rev Respir Dis 145:1301-5
Cruz, A A; Togias, A G; Lichtenstein, L M et al. (1992) Local application of atropine attenuates the upper airway reaction to cold, dry air. Am Rev Respir Dis 146:340-6
Pongracic, J A; Naclerio, R M; Reynolds, C J et al. (1991) A competitive kinin receptor antagonist, [DArg0, Hyp3, DPhe7]-bradykinin, does not affect the response to nasal provocation with bradykinin. Br J Clin Pharmacol 31:287-94
Freed, A N; Fuller, S D; Stream, C E (1991) Transient airway cooling modulates dry-air-induced and hypertonic aerosol-induced bronchoconstriction. Am Rev Respir Dis 144:358-62

Showing the most recent 10 out of 38 publications