Abstract

narrative) The responsibility of the Human Phenotyping Core is to perform the clinical protocols necessary to generate the data to assign phenotype status to the subjects. The core uses the resources of General Clinical Research Centers at two sites-the Brigham and Women's Hospital and the University of Utah Medical Center. All clinical protocols will be performed at both sites depending on the availability of a population that is the focus of each protocol. The same protocol techniques will be used at each site. They have had more than a decade of experience at these two facilities performing identical protocols. Statistical evaluation of the results obtained from each site does not demonstrate any site specific differences.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL055000-06
Application #
6464954
Study Section
Special Emphasis Panel (ZHL1)
Project Start
1996-02-01
Project End
2006-01-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Manosroi, Worapaka; Tan, Jia Wei; Rariy, Chevon M et al. (2017) The Association of Estrogen Receptor-? Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab 102:4124-4135
Gupta, Tina; Connors, Molly; Tan, Jia Wei et al. (2017) Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens 31:124-131
Tan, Jia W; Gupta, Tina; Manosroi, Worapaka et al. (2017) Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight 2:
Chong, Cherish; Hamid, Anis; Yao, Tham et al. (2017) Regulation of aldosterone secretion by mineralocorticoid receptor-mediated signaling. J Endocrinol 232:525-534
Baudrand, Rene; Pojoga, Luminita H; Vaidya, Anand et al. (2015) Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation 132:1825-33
Garza, Amanda E; Rariy, Chevon M; Sun, Bei et al. (2015) Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension 65:211-217
Brown, Jenifer M; Williams, Jonathan S; Luther, James M et al. (2014) Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension 63:273-80
Saxena, A R; Chamarthi, B; Williams, G H et al. (2014) Predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women. J Hum Hypertens 28:292-7
Garg, Rajesh; Sun, Bei; Williams, Jonathan (2014) Effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertension. Hypertension 64:1384-7
Brown, Jenifer M; Underwood, Patricia C; Ferri, Claudio et al. (2014) Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk. Hypertension 63:1205-11

Showing the most recent 10 out of 87 publications