Abstract

Specific Aim 1: To perform a prospective, randomized, placebo-controlled trial to evaluate efficacy of intracoronary autologous bone marrow-derived angioblasts on native heart function in LVAD recipients awaiting cardiac transplantation. Secondary end-points include measurement of neovascularization and cardiac regeneration in explanted native hearts, and determining whether a correlation exists between age and reduced numbers of mobilized bone marrow stem cells.
Specific Aim 2 : To identify the influence of adult bone marrow-derived angioblasts on mesenchymal stem cell migration, survival, proliferation and differentiation in vitro.
Specific Aim 3 : To determine if co-transplantation of angioblasts together with autologous mesenchymal stem cells enhances engraftment, myogenesis, and cardiac function in vivo after acute myocardial ischemia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL077096-04
Application #
7618139
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$625,160
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Sondermeijer, Hugo P; Witkowski, Piotr; Woodland, David et al. (2016) Optimization of alginate purification using polyvinylidene difluoride membrane filtration: Effects on immunogenicity and biocompatibility of three-dimensional alginate scaffolds. J Biomater Appl 31:510-520
Ascheim, Deborah D; Gelijns, Annetine C; Goldstein, Daniel et al. (2014) Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. Circulation 129:2287-96
Toba, Faustino A; Visai, Livia; Trivedi, Sheetal et al. (2013) The role of ionic interactions in the adherence of the Staphylococcus epidermidis adhesin SdrF to prosthetic material. FEMS Microbiol Lett 338:24-30
Gordon, Rachel J; Weinberg, Alan D; Pagani, Francis D et al. (2013) Prospective, multicenter study of ventricular assist device infections. Circulation 127:691-702
Gordon, Rachel J; Miragaia, Maria; Weinberg, Alan D et al. (2012) Staphylococcus epidermidis colonization is highly clonal across US cardiac centers. J Infect Dis 205:1391-8
See, Fiona; Seki, Tetsunori; Psaltis, Peter J et al. (2011) Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia. J Cell Mol Med 15:2117-29
Toba, Faustino A; Akashi, Hirokazu; Arrecubieta, Carlos et al. (2011) Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections. J Thorac Cardiovasc Surg 141:1259-64
Marshall, Randolph S; Lazar, Ronald M (2011) Pumps, aqueducts, and drought management: vascular physiology in vascular cognitive impairment. Stroke 42:221-6
Festa, Joanne R; Jia, Xiaoyu; Cheung, Ken et al. (2011) Association of low ejection fraction with impaired verbal memory in older patients with heart failure. Arch Neurol 68:1021-6
Sinha, Anshu; Shahzad, Khurram; Latif, Farhana et al. (2010) Peripheral blood mononuclear cell transcriptome profiles suggest T-cell immunosuppression after uncomplicated mechanical circulatory support device surgery. Hum Immunol 71:164-9

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