Abstract

This Core will provide integral support for the design, data management, analysis, and interpretation for each of the four projects. Specifically, the Core analysis activities will include 1) model-based (parametric) and model-free (nonparametric) linkage analysis; 2) family-based and case-control association testing for fine mapping; 3) quantitative trait loci (QTL) analysis and expression QTL analysis; 4) microarray analysis; and 5) model building and validation for prediction. In addition, the Core will interact with the Genotyping and Sequencing Core C and Clinical Core D, and the Projects to ensure the quality, reliability, safety, and availability of the relevant data and results. The Core will provide computational and informatics expertise and facilities to the Projects and other Cores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL077107-01
Application #
6892789
Study Section
Special Emphasis Panel (ZHL1-CSR-S (M1))
Project Start
2005-01-01
Project End
2009-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
1
Fiscal Year
2005
Total Cost
$299,695
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Xu, Huichun; Dorn 2nd, Gerald W; Shetty, Amol et al. (2018) A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. J Pers Med 8:
Kim, Dae Joong; Christofidou, Elena D; Keene, Douglas R et al. (2015) Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix. Mol Biol Cell 26:2640-54
Lauer, Michael S (2014) Personal reflections on big science, small science, or the right mix. Circ Res 114:1080-2
Gao, Hanxiang; Li, Lin; Rao, Shaoqi et al. (2014) Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families. PLoS One 9:e113935
Sossey-Alaoui, Khalid (2013) Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasis. Semin Cell Dev Biol 24:287-97
Tang, W H Wilson; Shrestha, Kevin; Tong, Wilson et al. (2013) Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction. Transl Res 162:26-33
Stenina-Adognravi, Olga (2013) Thrombospondins: old players, new games. Curr Opin Lipidol 24:401-9
Tang, W H Wilson; Shrestha, Kevin; Wang, Zeneng et al. (2013) Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure. J Card Fail 19:87-93
Timur, A A; Murugesan, G; Zhang, L et al. (2012) P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease. Int J Lab Hematol 34:473-83
Bhattacharyya, Sanghamitra; Sul, Kristina; Krukovets, Irene et al. (2012) Novel tissue-specific mechanism of regulation of angiogenesis and cancer growth in response to hyperglycemia. J Am Heart Assoc 1:e005967

Showing the most recent 10 out of 120 publications