Abstract

One fundamental theme of this SCCOR proposal is the development of genetic tools for understanding the mechanistic basis for diabetes-associated cardiovascular disease. The Applied Genomics Core (AGC, Core Unit B) will provide sample processing and analytical support to the Projects detailed in this application. Specifically, the AGC will: 1) Perform DNA extraction and analysis of single nucleotide polymorphisms and other genetic variants for Projects 4 and 5 of this application. 2) Provide gene informatics expertise to mine and annotate genetic variants in candidate genes will also be conducted to support Projects 1, 4, and 5.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL077113-04
Application #
7785978
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2008-01-01
Budget End
2008-12-31
Support Year
4
Fiscal Year
2008
Total Cost
$253,287
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Oni-Orisan, Akinyemi; Cresci, Sharon; Jones, Philip G et al. (2018) Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome. Prostaglandins Other Lipid Mediat 138:15-22
Patel, Krishna K; Arnold, Suzanne V; Chan, Paul S et al. (2018) Validation of the Seattle angina questionnaire in women with ischemic heart disease. Am Heart J 201:117-123
Coverstone, Edward D; Bach, Richard G; Chen, LiShiun et al. (2018) A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol 113:38
Patel, Krishna K; Arnold, Suzanne V; Jones, Philip G et al. (2018) Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction. Am J Cardiol 121:789-795
Thompson, Lauren E; Masoudi, Frederick A; Gosch, Kensey L et al. (2017) Gender differences in the association between discharge hemoglobin and 12-month mortality after acute myocardial infarction. Clin Cardiol 40:1279-1284
Zewinger, Stephen; Kleber, Marcus E; Tragante, Vinicius et al. (2017) Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. Lancet Diabetes Endocrinol 5:534-543
Pokharel, Yashashwi; Sharma, Puza P; Qintar, Mohammed et al. (2017) High-sensitivity C-reactive protein levels and health status outcomes after myocardial infarction. Atherosclerosis 266:16-23
Qintar, Mohammed; Spertus, John A; Tang, Yuanyuan et al. (2017) Noncardiac chest pain after acute myocardial infarction: Frequency and association with health status outcomes. Am Heart J 186:1-11
Pokharel, Yashashwi; Tang, Yuanyuan; Bhardwaj, Bhaskar et al. (2017) Association of low-density lipoprotein pattern with mortality after myocardial infarction: Insights from the TRIUMPH study. J Clin Lipidol 11:1458-1470.e4
Pitts, Reynaria; Daugherty, Stacie L; Tang, Fengming et al. (2017) Optimal secondary prevention medication use in acute myocardial infarction patients with nonobstructive coronary artery disease is modified by management strategy: insights from the TRIUMPH Registry. Clin Cardiol 40:347-355

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