Abstract

The Neutrophil Function Core will support both the clinical projects (Projects #1 and #2) and the mouse models project (Project #3). The two major activities of the core will be to screen donor blood products implicated in TRALI reactions (or random control products) for their ability to prime or activate neutrophils and monocytes/macrophages as well as survey the cytokine levels in these samples. Similarly, the core will also provide assistance in the mouse modeling project by surveying experimentally stored murine blood products for neutrophil priming activity as well as dkectly assessing neutrophil function in bone marrow, tissue and blood samples that will be generated in this project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL081027-05
Application #
7922631
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$177,564
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Toy, Pearl; Kleinman, Steven H; Looney, Mark R (2017) Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion 57:709-713
Roubinian, Nareg H; Looney, Mark R; Keating, Sheila et al. (2017) Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion 57:1684-1690
Roubinian, Nareg H; Looney, Mark R; Kor, Daryl J et al. (2015) Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion 55:1838-46
Toy, Pearl; Bacchetti, Peter; Grimes, Barbara et al. (2015) Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion 55:947-52
Feiner, John R; Gropper, Michael A; Toy, Pearl et al. (2015) A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology 123:126-35
Looney, Mark R; Roubinian, Nareg; Gajic, Ognjen et al. (2014) Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med 42:1676-87
Murphy, Edward L; Kwaan, Nicholas; Looney, Mark R et al. (2013) Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med 126:357.e29-38
Gandhi, Manish J; Carrick, Danielle M; Jenkins, Sarah et al. (2013) Lot-to-lot variability in HLA antibody screening using a multiplexed bead-based assay. Transfusion 53:1940-7
Rollins, Mark D; Molofsky, Ari B; Nambiar, Ashok et al. (2012) Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Crit Care Med 40:2488-91
Kor, Daryl J; Kashyap, Rahul; Weiskopf, Richard B et al. (2012) Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 185:842-50

Showing the most recent 10 out of 26 publications