This application requests continuation of support for a Mental Health Clinical Research Center designed to coordinate and integrate multidisciplinary research on the genetic epidemiology of psychiatric disorders. this multidisciplinary research is organized and coordinated by means of 8 MHCRC core facilities which have specific functions and goals. The Adult Assessment Unit and Registry systematically ascertains and classifies adult psychiatric patients. The Child Assessment Unit and Registry has the same role for child patients and family members. The population-based Twin and Birth Certificate registry systematically ascertains all twins and special groups of singletons born in Missouri after 1968. The Genetic Methodology Facility develops and extends quantitative methods for pedigree analysis. the biostatistical Consultation Facility provides consultation on experimental design and biostatistical analysis. The Tissue Culture and Neurochemistry Laboratory provides support and expertise in a variety of cell culture techniques, neurotransmitter receptor assays, and second messenger assays. The Human DNA Polymorphism Laboratory provides support and expertise in preparation of DNA and genotyping by a variety of molecular genetic techniques. All these facilities provide consultation and training in their areas of expertise. The Administrative Core monitors and coordinates all these activities. These core activities facilitate and integrate work of 27 independently funded projects in genetic epidemiology that are sponsored by the MHCRC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH031302-15
Application #
3107029
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1986-09-01
Project End
1996-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
15
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Todd, R D; Geller, B; Neuman, R et al. (1996) Increased prevalence of alcoholism in relatives of depressed and bipolar children. J Am Acad Child Adolesc Psychiatry 35:716-24