The proposed MHCRC will focus on Regional Brain function in schizophrenia. It will consist of seven cores. Core I - Administration; Core II - Accrual and Assessment will oversee patient flow and standard diagnostic procedures; Core III - Database Management and Statistics will supervise data entry and data analysis; Core IV - Neuropsychiatry has two components: 1. Neuropsychology. Administration of standard clinical batteries and development of new experimental tasks focusing on language, memory and affect. 2. Neuroimaging. This will include: MRI studies; PET and SPECT human studies and radioligand development; regional cerebral blood flow using the Xenon-133 and topographic EEG/EP. These techniques will provide measures of neuroanatomy and of neurophysiologic activity. A hierarchical use of methods with special emphasis on stimulation procedures is outlined. Core V -Genetics, will focus on family studies and establishment of all lines. Core VI - Neuropharmacology - will perform post-mortem neuroreceptor studies and Core VII - Neuropathology - will emphasize morphometric and immunohistochemical measurements. This scientific integration will provide insight into understanding schizophrenia as a brain disorder. This multidisciplinary approach is necessary for the development of a systematic program of research and on the application of neuropsychiatric methods to the study and treatment of schizophrenia. The MHCRC will coordinate activities of basic and clinical investigators and laboratories focusing on the advancement in the neurosciences applicable to schizophrenia. It will rely on the unique set of facilities and expertise available to schizophrenia. It will rely on the unique set of facilities and expertise available at the University of Pennsylvania for performing this work.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH043880-05
Application #
2245904
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1988-08-01
Project End
1996-07-31
Budget Start
1992-09-01
Budget End
1993-07-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
van Erp, Theo G M; Thompson, Paul M; Kieseppä, Tuula et al. (2012) Hippocampal morphology in lithium and non-lithium-treated bipolar I disorder patients, non-bipolar co-twins, and control twins. Hum Brain Mapp 33:501-10
Moberg, P J; Doty, R L; Mahr, R N et al. (1997) Olfactory identification in elderly schizophrenia and Alzheimer's disease. Neurobiol Aging 18:163-7