Abstract

Project proposes in vivo functional and structural neuroimaging, neurobehavioral studies, and postmortem histologic studies of schizophrenic patients designed to delineate the neural substrate of disturbed frontal lobe function in schizophrenia. We will focus on problems of spatial cognition and volition using oculomotor tasks for which the neurophysiologic substrates in dorsolateral prefrontal cortex (DLPFC) have been well-characterized by unit recording studies in non- human primates. We will focus on the integrity of the frontal eye fields (FEF), which receive substantial associational projections from DLPFC and which are believed to be a site of abnormalities causing eye movement dysfunctions in schizophrenia. Project is closely linked to Project-Lewis (which proposed postmortem histologic studies of DLPFC that parallel both our in vivo neuroimaging studies of that region as well as our histologic studies of FEF), Project-Levitt (which will conduct gene expression studies of FEF in postmortem tissue from schizophrenic patients), Project 6-Olson (which proposes unit recording studies of behaving monkeys performing the identical oculomotor tasks to be used in our clinical studies), and Project-Cohen (which proposes fMRI and cognitive studies of working memory disturbances in schizophrenia that parallel those proposed in this project).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045156-13
Application #
6615246
Study Section
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
13
Fiscal Year
2002
Total Cost
$228,564
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Cai, HuaLin; Zhou, Xiang; Dougherty, George G et al. (2018) Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology 90:43-51
Stevenson, J M; Reilly, J L; Harris, M S H et al. (2016) Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. Transl Psychiatry 6:e739
Lizano, Paulo L; Keshavan, Matcheri S; Tandon, Neeraj et al. (2016) Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. Schizophr Res 170:115-22
Bishop, Jeffrey R; Reilly, James L; Harris, Margret S H et al. (2015) Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology (Berl) 232:145-54
Horton, Leslie E; Tarbox, Sarah I; Olino, Thomas M et al. (2015) Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study. Psychiatry Res 227:339-46
Hall, Nathan; Colby, Carol (2014) S-cone visual stimuli activate superior colliculus neurons in old world monkeys: implications for understanding blindsight. J Cogn Neurosci 26:1234-56
Subramanian, Janani; Colby, Carol L (2014) Shape selectivity and remapping in dorsal stream visual area LIP. J Neurophysiol 111:613-27
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Lencer, Rebekka; Bishop, Jeffrey R; Harris, Margret S H et al. (2014) Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci 264:345-55
McCracken, Clinton B; Grace, Anthony A (2013) Persistent cocaine-induced reversal learning deficits are associated with altered limbic cortico-striatal local field potential synchronization. J Neurosci 33:17469-82

Showing the most recent 10 out of 382 publications