Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI063331-16
Application #
9964988
Study Section
Special Emphasis Panel (NSS)
Program Officer
Davidson, Wendy F
Project Start
2020-12-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
16
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Conos, Stephanie A; Chen, Kaiwen W; De Nardo, Dominic et al. (2017) Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A 114:E961-E969
He, Yuan; Zeng, Melody Y; Yang, Dahai et al. (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354-7
He, Yuan; Hara, Hideki; Núñez, Gabriel (2016) Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends Biochem Sci 41:1012-1021
Yang, Dahai; He, Yuan; Muñoz-Planillo, Raul et al. (2015) Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. Immunity 43:923-32
Bronner, Denise N; Abuaita, Basel H; Chen, Xiaoyun et al. (2015) Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity 43:451-62
Symington, J W; Wang, C; Twentyman, J et al. (2015) ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1?-dependent manner. Mucosal Immunol 8:1388-99
De la Fuente, Marjorie; Franchi, Luigi; Araya, Daniela et al. (2014) Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int J Med Microbiol 304:384-92
Shaw, Michael H; Kamada, Nobuhiko; Warner, Neil et al. (2011) The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation. Trends Immunol 32:73-9
Reimer, Thornik; Shaw, Michael H; Franchi, Luigi et al. (2010) Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol 40:764-9
Franchi, Luigi; Muñoz-Planillo, Raul; Reimer, Thornik et al. (2010) Inflammasomes as microbial sensors. Eur J Immunol 40:611-5

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