Core A will coordinate the resources and facilities necessary for attaining the scientific mission of the CCNMD. It will have four complementary functions: 1. Administrative Coordination of CCNMD investigators, trainees and personnel will include implementation of NIH, University and IRB guidelines of fiscal monitoring, allocation of resources, progress reports, grant preparation, human subjects and animal protocols; review new initiatives; provide liaison with University and Community; establish policies when indicated. 2. Academic Coordination among CCNMD investigators, trainees and personnel will include communication of findings across CCNMD laboratories; integration of educational activities, such as seminars and presentations of speakers; liaison with neuroscience interest groups across campus and in other academic settings; recruitment of highly qualified predoctoral and postdoctoral trainees. The CCNMD will maintain a comprehensive outreach program to the community that will contribute to dissemination of information regarding basic and clinical neuroscience research in schizophrenia through speakers in local, regional and national meetings and in an openhouse format, inviting the public to Penn. With Core B and Projects, this Core will coordinate the Center's website, ensure access to data, research tools and biological material generated by the Center, and facilitate interaction with the Advisory Board. 3. Recruitment and assessment for CCNMD human Projects (I, II, V). Standardized procedures will be applied to participants with schizophrenia and healthy people. This will include evaluation of medical, neurological and psychiatric status and computerized neurocognitive measures. The Core will assess systematically the clinical history and presentation of individuals whose brains are donated for postmortem research in Project V and coordinate data transfer to Data and Biostatistics Core (Core B) and Projects (I, II, V, VI). Core A will maintain a registry for future studies and integrative projects, and provide training in clinical neuroscience assessment to graduate students, fellows and investigators in the Center and collaborating programs. 4. Allocation of participants to animal projects will provide coordination of the protocols, tracking with the Core B the flow of participants across Projects III, IV and V and work closely with investigators and research personnel in the animal projects to ensure that the scientific goals are met. This will be done in parallel to the human studies maintaining high level of integration across the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH064045-02
Application #
6653365
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P et al. (2018) Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry 84:644-654
Walton, E; Hibar, D P; van Erp, T G M et al. (2017) Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatr Scand 135:439-447
Barz, Claudia S; Bessaih, Thomas; Abel, Ted et al. (2016) Sensory encoding in Neuregulin 1 mutants. Brain Struct Funct 221:1067-81
Satterthwaite, Theodore D; Wolf, Daniel H; Calkins, Monica E et al. (2016) Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms. JAMA Psychiatry 73:515-24
Welle, Cristin G; Contreras, Diego (2016) Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry. J Neurophysiol 115:1821-35
Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha et al. (2016) The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth. Neuroimage 124:1115-9
Barz, Claudia S; Bessaih, Thomas; Abel, Ted et al. (2016) Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1. Brain Struct Funct 221:4383-4398
Collier, Azurii K; Wolf, Daniel H; Valdez, Jeffrey N et al. (2014) Subsequent memory effects in schizophrenia. Psychiatry Res 224:211-7
Müller, Veronika I; Kellermann, Tanja S; Seligman, Sarah C et al. (2014) Modulation of affective face processing deficits in Schizophrenia by congruent emotional sounds. Soc Cogn Affect Neurosci 9:436-44
Glen Jr, W Bailey; Horowitz, Bryant; Carlson, Gregory C et al. (2014) Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning. Hippocampus 24:204-13

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