Abstract

This Core serves three main functions for the Center: 1. Database collection and maintenance for participation in the NINDS Head Injury Center data collection effort. Here, the minimum data set to be specified by the Stroke and Trauma Division of NINDS will be collected and computerized. 2. Outcome tool validation studies will determine the relationships and interobserver variability between the Functional Impairment Measure (FIM), Philadelphia Brain Impairment Scale (PBIS) and Injury Impairment Scale (IIS) and the Glasgow Outcome Score (GOS). 3. Biostatistical Support of Center activities will assist investigators in study design, in data management and in statistical analyses where necessary.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS008803-27
Application #
6112030
Study Section
Project Start
1998-08-01
Project End
2000-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
27
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Nariai, Hiroki; Duberstein, Susan; Shinnar, Shlomo (2018) Treatment of Epileptic Encephalopathies: Current State of the Art. J Child Neurol 33:41-54
Nariai, Hiroki; Beal, Jules; Galanopoulou, Aristea S et al. (2017) Scalp EEG Ictal gamma and beta activity during infantile spasms: Evidence of focality. Epilepsia 58:882-892
Tomasevic, Gregor; Laurer, Helmut L; Mattiasson, Gustav et al. (2012) Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA. J Neurosurg 116:1368-78
Browne, Kevin D; Chen, Xiao-Han; Meaney, David F et al. (2011) Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma 28:1747-55
Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23
Hånell, Anders; Clausen, Fredrik; Björk, Maria et al. (2010) Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma 27:1297-309
Marklund, N; Morales, D; Clausen, F et al. (2009) Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. Neuroscience 163:540-51
Marklund, Niklas; Bareyre, Florence M; Royo, Nicolas C et al. (2007) Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression. J Neurosurg 107:844-53
Keck, Carrie A; Thompson, Hilaire J; Pitkanen, Asla et al. (2007) The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury. Restor Neurol Neurosci 25:77-90
Serbest, Gulyeter; Burkhardt, Matthew F; Siman, Robert et al. (2007) Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice. Neurochem Res 32:2006-14

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