Abstract

The critical care aspect of the core will be responsible for maintaining high quality pre-hospital, emergency department, and ICU care of TBI patients entered into the clinical projects of this Center proposal. It will closely monitor randomization procedures, data collection, and timely transfer of data to the Data Analysis/Biostatistics/Epidemiology Core. The University of Pittsburgh Medical Center has authorized Dr. Marion, the Center Director and PI for this core, to determine all pre- hospital and emergency department protocols pertaining to brain injury, and this has allowed a great deal of uniformity in the way in which these patients are evaluated and treated. Such uniformity will enhance the scientific credibility of our clinical studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS030318-07
Application #
6273801
Study Section
Project Start
1998-03-01
Project End
1999-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Ikonomovic, Milos D; Mi, Zhiping; Abrahamson, Eric E (2017) Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders. Ageing Res Rev 34:51-63
Osier, Nicole D; Bales, James W; Pugh, Bunny et al. (2017) Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury. J Neurotrauma 34:86-96
Jackson, Edwin K; Kotermanski, Shawn E; Menshikova, Elizabeth V et al. (2017) Adenosine production by brain cells. J Neurochem 141:676-693
Willyerd, F Anthony; Empey, Philip E; Philbrick, Ashley et al. (2016) Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma 33:226-31
Janata, Andreas; Magnet, Ingrid A M; Uray, Thomas et al. (2014) Regional TNF? mapping in the brain reveals the striatum as a neuroinflammatory target after ventricular fibrillation cardiac arrest in rats. Resuscitation 85:694-701
Drabek, Tomas; Janata, Andreas; Wilson, Caleb D et al. (2014) Minocycline attenuates brain tissue levels of TNF-? produced by neurons after prolonged hypothermic cardiac arrest in rats. Resuscitation 85:284-91
Alexander, Sheila A; Ren, Dianxu; Gunn, Scott R et al. (2014) Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care 23:49-57
Conley, Yvette P; Okonkwo, David O; Deslouches, Sandra et al. (2014) Mitochondrial polymorphisms impact outcomes after severe traumatic brain injury. J Neurotrauma 31:34-41
Abrahamson, Eric E; Foley, Lesley M; Dekosky, Steven T et al. (2013) Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice. J Cereb Blood Flow Metab 33:826-33
Cousar, J'mir L; Conley, Yvette P; Willyerd, F Anthony et al. (2013) Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury. Neurocrit Care 19:192-8

Showing the most recent 10 out of 116 publications