Abstract

Core C- Data Analysis, Data management and Data Entry Core Dr. Richard J. Kryscio, Professor of Statistics and Director of the Biostatistics Consulting Unit, will direct the Data Analysis and Data Management Core. Dr. Kryscio has over 20 years of experience consulting on projects in biomedicine. He is familiar with the analysis of behavioral, neurochemical, morphological, and electrochemical endpoints taken on rhesus monkeys that have parkinsonian symptoms that have been treated with vehicle or GDNF. Dr. Anders H. Andersen will be in charge of the analysis of the fMRI data. Dr. Andersen has over 15 years of experience in biomedical signal and image data analysis, especially in the area of MRI and fMRI data. Mike Dunlap is responsible for data entry and for the daily maintenance of the database shared by all projects and cores.
The specific aims of the Data Analysis and Data Management Core are to: 1. advise all investigators in the Udall Center on issues related to experimental design and data analysis. 2. perform the statistical analysis of the main endpoints in each of the projects and cores. 3. provide quantitative assessments of each fMRI session recorded in Project 2. 4. correlate the findings among the projects. 5. establish and maintain a centralized database for the studies on monkeys.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS039787-10
Application #
7904809
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
10
Fiscal Year
2009
Total Cost
$88,746
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Stenslik, M J; Evans, A; Pomerleau, F et al. (2018) Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques. J Neurosci Methods 303:30-40
Stenslik, Mallory J; Potts, Lisa F; Sonne, James W H et al. (2015) Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease. J Neurosci Methods 251:120-9
Fan, X T; Zhao, F; Ai, Y et al. (2014) Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency. Brain Res 1552:34-40
Fuqua, Joshua L; Littrell, Ofelia M; Lundblad, Martin et al. (2014) Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro. Peptides 54:1-8
Stephens, Michelle L; Williamson, Anne; Deel, Megan E et al. (2014) Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure. Epilepsia 55:1817-25
Littrell, Ofelia M; Granholm, Ann-Charlotte; Gerhardt, Greg A et al. (2013) Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacol Biochem Behav 104:10-9
Littrell, O M; Fuqua, J L; Richardson, A D et al. (2013) A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides 47:43-9
van Bregt, Daniel R; Thomas, Theresa Currier; Hinzman, Jason M et al. (2012) Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat. Exp Neurol 234:8-19
Littrell, Ofelia M; Pomerleau, Francois; Huettl, Peter et al. (2012) Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiol Aging 33:427.e1-14
Stephens, Michelle L; Quintero, Jorge E; Pomerleau, Francois et al. (2011) Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus. Neurobiol Aging 32:811-20

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