Abstract

The Imaging Core will provide essential support for the PET studies (Projects 1-3) and the MR studies (Project 2) proposed in this application. In these studies, multiple radiotracers will be administered intravenously to all research participants in conjunction with PET imaging. In Project 1, Parkinson's disease (PD) patients and healthy volunteer subjects will be scanned with [ [18] F]-FDG PET (to measure glucose metabolism), [[15] 0]-H20 PET (to visualize cerebral blood flow) and [ [82]Rb] PET (to assess blood brain barrier (BBB) permeability). In Project 2, PD patients will be scanned with [18] F-FDG (for glucose metabolism), [[11] C]-PIB (to detect protein aggregation), and [[18] F]-FPCIT (to trace striatal dopamine transporter binding). In Project 3, subjects will also undergo FPCIT PET imaging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS071675-03
Application #
8382428
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$136,824
Indirect Cost
$54,400

  Institution

Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030

  Publications

Ko, Ji Hyun; Spetsieris, Phoebe G; Eidelberg, David (2018) Network Structure and Function in Parkinson's Disease. Cereb Cortex 28:4121-4135
Nazem, Amir; Tang, Chris C; Spetsieris, Phoebe et al. (2018) A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia. Alzheimers Dement (Amst) 10:583-594
Ge, Jingjie; Wu, Jianjun; Peng, Shichun et al. (2018) Reproducible network and regional topographies of abnormal glucose metabolism associated with progressive supranuclear palsy: Multivariate and univariate analyses in American and Chinese patient cohorts. Hum Brain Mapp 39:2842-2858
Argyelan, Miklos; Herzallah, Mohammad; Sako, Wataru et al. (2018) Dopamine modulates striatal response to reward and punishment in patients with Parkinson's disease: a pharmacological challenge fMRI study. Neuroreport 29:532-540
Lerner, Renata P; Francardo, Veronica; Fujita, Koji et al. (2017) Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia. Sci Rep 7:16005
Hendershott, Taylor R; Zhu, Delphine; Llanes, Seoni et al. (2017) Domain-specific accuracy of the Montreal Cognitive Assessment subsections in Parkinson's disease. Parkinsonism Relat Disord 38:31-34
Jourdain, Vincent A; Schindlbeck, Katharina A; Tang, Chris C et al. (2017) Increased putamen hypercapnic vasoreactivity in levodopa-induced dyskinesia. JCI Insight 2:
Tomše, Petra; Jensterle, Luka; Rep, Sebastijan et al. (2017) The effect of 18F-FDG-PET image reconstruction algorithms on the expression of characteristic metabolic brain network in Parkinson's disease. Phys Med 41:129-135
Ng, Bernard; Varoquaux, Gael; Poline, Jean Baptiste et al. (2017) Distinct alterations in Parkinson's medication-state and disease-state connectivity. Neuroimage Clin 16:575-585
Vo, An; Sako, Wataru; Fujita, Koji et al. (2017) Parkinson's disease-related network topographies characterized with resting state functional MRI. Hum Brain Mapp 38:617-630

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