Abstract

The primary objecfive of the Clinical Resource Core (CRC) is to provide comprehensive programs for recruitment, community outreach and educafion, core clinical assessments, and genotyping and biological sample storage for all projects of the Udall Center. The CRC will also serve a coordinafion role between projects and cores to assure that all subjects participating in the projects of our Udall Center will complete a minimal multidisciplinary dataset, including the following: clinical rafings (off-state UPDRS), a standardized neuropsychological testing battery (see Cognitive and Behavioral core), off-state FDG PET, off-state, routine anatomical MRI, DNA banking (see below), and brain donation and banking when applicable. Data collected through the CRC will be shared with other Udail Centers and PD invesfigators at other institutions through the PD-DOC registry (see Stafisfics and Data Management Core).

Public Health Relevance

This core will serve a critical funcfion in the proposed Udall Center by coordinating all aspects of subject recruitment, clinical assessments, as well as providing support for several of the anticipated investigational procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS071675-05
Application #
8742002
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
5
Fiscal Year
2014
Total Cost
$113,169
Indirect Cost
$44,994

  Institution

Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030

  Publications

Ko, Ji Hyun; Spetsieris, Phoebe G; Eidelberg, David (2018) Network Structure and Function in Parkinson's Disease. Cereb Cortex 28:4121-4135
Nazem, Amir; Tang, Chris C; Spetsieris, Phoebe et al. (2018) A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia. Alzheimers Dement (Amst) 10:583-594
Ge, Jingjie; Wu, Jianjun; Peng, Shichun et al. (2018) Reproducible network and regional topographies of abnormal glucose metabolism associated with progressive supranuclear palsy: Multivariate and univariate analyses in American and Chinese patient cohorts. Hum Brain Mapp 39:2842-2858
Argyelan, Miklos; Herzallah, Mohammad; Sako, Wataru et al. (2018) Dopamine modulates striatal response to reward and punishment in patients with Parkinson's disease: a pharmacological challenge fMRI study. Neuroreport 29:532-540
Lerner, Renata P; Francardo, Veronica; Fujita, Koji et al. (2017) Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia. Sci Rep 7:16005
Hendershott, Taylor R; Zhu, Delphine; Llanes, Seoni et al. (2017) Domain-specific accuracy of the Montreal Cognitive Assessment subsections in Parkinson's disease. Parkinsonism Relat Disord 38:31-34
Jourdain, Vincent A; Schindlbeck, Katharina A; Tang, Chris C et al. (2017) Increased putamen hypercapnic vasoreactivity in levodopa-induced dyskinesia. JCI Insight 2:
Tomše, Petra; Jensterle, Luka; Rep, Sebastijan et al. (2017) The effect of 18F-FDG-PET image reconstruction algorithms on the expression of characteristic metabolic brain network in Parkinson's disease. Phys Med 41:129-135
Ng, Bernard; Varoquaux, Gael; Poline, Jean Baptiste et al. (2017) Distinct alterations in Parkinson's medication-state and disease-state connectivity. Neuroimage Clin 16:575-585
Vo, An; Sako, Wataru; Fujita, Koji et al. (2017) Parkinson's disease-related network topographies characterized with resting state functional MRI. Hum Brain Mapp 38:617-630

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