The Specific Pathogen-Free (SPF) Macaque Breeding and AIDS Infrastructure Unit provides core resources for microbiology and flow cytometry supporting AIDS research programs and the SPF Macaque Breeding program. Proposed activities include microbiologic surveillance of the Center's macaque resources necessary to eliminate spontaneous retroviruses and Herpesvirus simiae. Well-characterized nonhuman primates (NHPs) free of potentially confounding infectious agents are essential to identify specific virus-host interactions that contrIbute to immunodeficiency disease pathogenesis. Standardized serologic and antigen capture assays will be developed as a core service to facilitate Center and collaborative research programs utilizing the SIVmac/rhesus macaque experimental model. Pig-tailed macaques have recently been shown to be susceptible to infection with HIV-1. In vitro susceptibility of macaque peripheral blood leukocytes to SIV and HIV-1 infection will be used in conjunction with random amplified polymorphic DNA polymorphism as a strategy to identify possible genetic markers of pig-tailed macaque susceptibility to lentivirus infection. Proposed renovations will provide critically needed virology laboratory space for the new Head of the Infectious Diseases Division, current research programs, and collaborative research programs from the Oregon Health Sciences University.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000163-35A1
Application #
3763930
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006
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Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Toro, C A; Aylwin, C F; Lomniczi, A (2018) Hypothalamic epigenetics driving female puberty. J Neuroendocrinol 30:e12589
Bulgarelli, Daiane L; Ting, Alison Y; Gordon, Brenda J et al. (2018) Development of macaque secondary follicles exposed to neutral red prior to 3-dimensional culture. J Assist Reprod Genet 35:71-79
Prola-Netto, Joao; Woods, Mark; Roberts, Victoria H J et al. (2018) Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure. Radiology 286:122-128
Moccetti, Federico; Brown, Eran; Xie, Aris et al. (2018) Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries. J Am Coll Cardiol 72:1015-1026
Blue, Steven W; Winchell, Andrea J; Kaucher, Amy V et al. (2018) Simultaneous quantitation of multiple contraceptive hormones in human serum by LC-MS/MS. Contraception 97:363-369
Jeon, Sookyoung; Li, Qiyao; Rubakhin, Stanislav S et al. (2018) 13C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study. Nutr Res :
Slayden, Ov Daniel; Friason, Francis Kathryn E; Bond, Kise Rosen et al. (2018) Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol 47:362-370
Dissen, G A; Adachi, K; Lomniczi, A et al. (2017) Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. Reprod Domest Anim 52 Suppl 2:354-358

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