Inhibition of Human Cytochrome P450 1A2 by Furafylline

Kunze, Kent L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29GM048750-04
• Application #: 2186291
• Study Section: Toxicology Subcommittee 2 (TOX)
• Project Start: 1993-08-01
• Project End: 1998-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: University of Washington
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 135646524
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Racha, J K; Rettie, A E; Kunze, K L (1998) Mechanism-based inactivation of human cytochrome P450 1A2 by furafylline: detection of a 1:1 adduct to protein and evidence for the formation of a novel imidazomethide intermediate. Biochemistry 37:7407-19

Kunze, K L; Wienkers, L C; Thummel, K E et al. (1996) Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos 24:414-21

Kunze, K L; Trager, W F (1996) Warfarin-fluconazole. III. A rational approach to management of a metabolically based drug interaction. Drug Metab Dispos 24:429-35

McHugh, T E; Atkins, W M; Racha, J K et al. (1996) Binding of the aflatoxin-glutathione conjugate to mouse glutathione S-transferase A3-3 is saturated at only one ligand per dimer. J Biol Chem 271:27470-4

Labroo, R B; Thummel, K E; Kunze, K L et al. (1995) Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism. Drug Metab Dispos 23:490-6

Kunze, K L; Trager, W F (1993) Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol 6:649-56