This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonhuman primates (NHPs), particularly old world monkeys, are essential animal models for a host of human infectious diseases, including HIV/AIDS, herpes family virus infections, tuberculosis, malaria, influenza, hepatitis A/B, poliovirus, and many Class A bioterrorism agents such as smallpox, monkeypox, yersinia, and hemorrhagic fever viruses. The organization and function of the immune system in these animals closely resembles that of humans and, thus, NHPs provide an invaluable resource for the study of pathogenesis and immunity of these infections, the development of vaccines and other immunotherapeutics to such agents, and, just as importantly, investigation of fundamental questions in basic primate immunology that due to ethical or practical constraints are not amenable to study in the human system. Despite this potential, such investigations to date have been severely limited by lack of the necessary tools and expertise to perform and correctly interpret incisive studies of NHP immunobiology. The goal of this program is to develop the physical and informational tools required for comprehensive immunologic testing in NHP models. Accomplishing this goal will require attention to three parallel tracks of investigation: 1) identification, development, and validation of optimized reagents, 2) development of optimized protocols for the use of these reagents and paradigms for their interpretation, and 3) application of these reagents, protocols and paradigms to selected animal systems so as to define the fundamental immune physiology of the species in question (normal values, usual kinetics, etc. - information required for planning and interpreting any in vivo experiment or trial). This information will be used to formulate sophisticated, validated, and interpretable assays for immune assessment in NHP - immunotools that will significantly benefit the evaluation of any infection, immunologic disease, immunotherapy or vaccine system studied in these species, and will feed back to improve similar testing in humans.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000163-47
Application #
7348927
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
47
Fiscal Year
2006
Total Cost
$131,162
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
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Slayden, Ov Daniel; Friason, Francis Kathryn E; Bond, Kise Rosen et al. (2018) Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol 47:362-370
Dissen, G A; Adachi, K; Lomniczi, A et al. (2017) Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. Reprod Domest Anim 52 Suppl 2:354-358

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