This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This program study is designed to investigate (a) the development of perirhinal corex functions in monkeys, (b) the long-term consequences of early perirhinal cortex insult on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year of support, we have continued to behaviorally trained monkeys that we have prepared with neonatal lesions of the hippocampus and their sham-operated controls as they are reaching adolescence and early adulthood. We have assessed their ability to recognize objects and places over long delays, to hold information on line while performing a task, as well as their social skills and emotional reactivity. Through such research, principles of the brain's response to trauma can be established that will lead ultimately to the discovery of ways in which such effects can be alleviated or even eliminated.
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