Currently nonhuman primates are the only species that are susceptible to simian immunodeficiency virus (SIV) and develop a disease nearly identical to that seen in humans infected with HIV. In humans infected with HIV the individual response to infection is variable and particular patients demonstrate marked variability in chronologic progression to clinical AIDS. The time interval between infection and clinical disease is highly variable and depends on both viral and host factors. A small percentage of infected patients apparently are able to resist disease progression; research into the viral/host factors may provide information of clinical and therapeutic importance and these long-term survivors may be an important group to study. We currently have 4 M. nemestrina that have been infected with SIV/HIV for years and fall into the category of long-term survivors. None of these animals has yet progressed to clinical AIDS. These animals are important to maintain for f uture rese arch and provide an important animal model for disease progression and pathogenesis in individuals surviving infection for long periods of time. One M. nemestrina was inoculated with SIVMne E11S in 1988 and has remained seronegative although virus was isolated from this animal at 174 and 195 weeks post-inoculation. This animal has developed a significant decline in CD4+ cells but has yet to develop disease. In addition, 3 M. nemestrina were inoculated with HIV-1 as reported in 1992 and virus has not been isolated since 10 weeks post-inoculation. Two of the animals remain strongly seropositive, which provides strong evidence for continued viral replication. To date these animals have not progressed to clinical disease. FUNDING NIH grant RR00166.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

Showing the most recent 10 out of 320 publications