This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To identify peptides that modulate ingestive behavior in primates. Obesity has reached epidemic proportions in developed countries and this is having a profoundly negative impact on health and health care systems. Several peptides have recently been identified that may regulate appetite and feeding behaviors. We have been evaluating the effects of central and peripheral administration of these substances and their antagonists in rhesus monkeys, with the long-term aim of reducing obesity and ameliorating its consequences. In an effort to enhance the model we are using to study obesity, we developed and tested a fat-enriched maintenance diet. The diet was found to be highly palatable to rhesus monkeys and effective in increasing caloric intake. This research used WNPRC Animal Services and Aging Resources. The work provided the basis for a Master of Science degree for a student in the Department of Nutritional Sciences.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000167-48
Application #
7958734
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2009-05-01
Project End
2010-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
48
Fiscal Year
2009
Total Cost
$46,835
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kang, HyunJun; Mesquitta, Walatta-Tseyon; Jung, Ho Sun et al. (2018) GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition. Stem Cell Reports 11:197-211
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