This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Understanding the earliest events in vaginal transmission of HIV is critical to the development of interventions to prevent the sexual transmission of HIV. The goal of this project is to identify the earliest target cells after vaginal SIV transmission and characterize the pathway that used by the virus and virus-infected cells to reach the systemic circulation and peripheral lymphoid tissues.
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