Component V - Topiramate Treatment of Problem Drinkers The proposed study is a 12-week trial comparing topiramate (TOP), at a dosage of 200 mg/day, with an inactive placebo. We will randomly assign 160 problem drinkers (i.e., heavy drinkers without evidence of physical dependence on alcohol) who want to reduce their drinking. It is estimated that 30% of the general population are problem drinkers (NIAAA 2007). Despite its high prevalence, problem drinkers are understudied, particularly with respect to medications that may help them to reduce their drinking to safe levels. The study will extend to this patient population findings from a trial of TOP, which showed the drug to be well tolerated and efficacious in moderately-severe alcohol-dependent patients (Johnson et al. 2003).
The aims of the present study are to examine: 1) TOP'S safety and efficacy in reducing drinking and heavy drinking, 2) the relations among medication, daily mood, expectancies, and drinking behavior, and 3) the durability of TCP's effects during a six-month post-treatment follow-up period. A fourth, exploratory aim, is to estimate the effect size of variation in genes encoding GABA and glutamate receptors as moderators of both the therapeutic and adverse effects of TOP. The study will use interactive voice response technology to collect daily measures of drinking, mood, and medication usage. Biological measures of alcohol consumption (i.e., GGTP and CDT) will be used to validate self-reports. Hierarchical linear modeling will be used to examine effects at the between-person and within-person levels of analysis. Careful evaluation of the study's hypotheses will provide important information on the efficacy and mechanism of effects of TOP as a treatment for problem drinkers.
|Weiss, Nicole H; Bold, Krysten W; Contractor, Ateka A et al. (2018) Trauma exposure and heavy drinking and drug use among college students: Identifying the roles of negative and positive affect lability in a daily diary study. Addict Behav 79:131-137|
|Armeli, Stephen; Covault, Jonathan; Tennen, Howard (2018) Long-term changes in the effects of episode-specific drinking to cope motivation on daily well-being. Psychol Addict Behav 32:715-726|
|Higgins-Biddle, John C; Babor, Thomas F (2018) A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. Am J Drug Alcohol Abuse 44:578-586|
|Petry, Nancy M; Zajac, Kristyn; Ginley, Meredith K (2018) Behavioral Addictions as Mental Disorders: To Be or Not To Be? Annu Rev Clin Psychol 14:399-423|
|Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53|
|Bauer, Lance O (2018) Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse. Drug Alcohol Depend 191:300-308|
|Rash, Carla J; Petry, Nancy M; Alessi, Sheila M (2018) A randomized trial of contingency management for smoking cessation in the homeless. Psychol Addict Behav 32:141-148|
|Bauer, Lance O (2018) HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation. J Neurovirol 24:577-586|
|Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809|
|Zajac, Kristyn; Ginley, Meredith K; Chang, Rocio et al. (2017) Treatments for Internet gaming disorder and Internet addiction: A systematic review. Psychol Addict Behav 31:979-994|
Showing the most recent 10 out of 238 publications